ID:CBPC6_HUMAN DESCRIPTION: RecName: Full=Cytosolic carboxypeptidase 6; EC=3.4.17.-; AltName: Full=ATP/GTP-binding protein-like 4; FUNCTION: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity). COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Interacts with MYLK (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity). SIMILARITY: Belongs to the peptidase M14 family. SEQUENCE CAUTION: Sequence=BAG52938.1; Type=Frameshift; Positions=501; Sequence=BAG57648.1; Type=Frameshift; Positions=501;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5VU57
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.