Human Gene ERI3 (ENST00000372257.7) from GENCODE V38
  Description: Homo sapiens ERI1 exoribonuclease family member 3 (ERI3), transcript variant 1, mRNA. (from RefSeq NM_024066)
Gencode Transcript: ENST00000372257.7
Gencode Gene: ENSG00000117419.16
Transcript (Including UTRs)
   Position: hg38 chr1:44,221,070-44,355,257 Size: 134,188 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr1:44,221,558-44,355,026 Size: 133,469 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:44,221,070-44,355,257)mRNA (may differ from genome)Protein (337 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=ERI1 exoribonuclease 3; EC=3.1.-.-; AltName: Full=Prion interactor 1; AltName: Full=Prion protein-interacting protein;
COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
SUBUNIT: Interacts with PRNP (By similarity).
SIMILARITY: Contains 1 exonuclease domain.
SEQUENCE CAUTION: Sequence=AAC19158.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.48 RPKM in Testis
Total median expression: 1016.98 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -128.90231-0.558 Picture PostScript Text
3' UTR -215.70488-0.442 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006055 - Exonuclease
IPR013520 - Exonuclease_RNaseT/DNA_pol3
IPR012337 - RNaseH-like_dom

Pfam Domains:
PF00929 - Exonuclease

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

ModBase Predicted Comparative 3D Structure on O43414
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGD  WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006259 DNA metabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis

-  Descriptions from all associated GenBank mRNAs
  AF007157 - Homo sapiens clone 23856 unknown mRNA, partial cds.
BC144384 - Homo sapiens cDNA clone IMAGE:9052905.
AK026596 - Homo sapiens cDNA: FLJ22943 fis, clone KAT08662, highly similar to AF007157 Homo sapiens clone 23856 unknown mRNA.
BC001072 - Homo sapiens exoribonuclease 3, mRNA (cDNA clone IMAGE:2819900), complete cds.
BC004456 - Homo sapiens exoribonuclease 3, mRNA (cDNA clone IMAGE:2819900), complete cds.
AK293833 - Homo sapiens cDNA FLJ60449 complete cds, highly similar to Homo sapiens prion protein interacting protein (PRNPIP), mRNA.
AK297708 - Homo sapiens cDNA FLJ56336 complete cds, highly similar to Homo sapiens prion protein interacting protein (PRNPIP), mRNA.
AK290567 - Homo sapiens cDNA FLJ77066 complete cds, highly similar to Homo sapiens prion protein interacting protein (PRNPIP), mRNA.
KJ903138 - Synthetic construct Homo sapiens clone ccsbBroadEn_12532 ERI3 gene, encodes complete protein.
BC156812 - Synthetic construct Homo sapiens clone IMAGE:100062500, MGC:190531 exoribonuclease 3 (ERI3) mRNA, encodes complete protein.
AB528814 - Synthetic construct DNA, clone: pF1KE0284, Homo sapiens PRNPIP gene for exoribonuclease 3, without stop codon, in Flexi system.
JD037157 - Sequence 18181 from Patent EP1572962.
JD389181 - Sequence 370205 from Patent EP1572962.
JD243555 - Sequence 224579 from Patent EP1572962.
JD191105 - Sequence 172129 from Patent EP1572962.
JD023035 - Sequence 4059 from Patent EP1572962.
JD031114 - Sequence 12138 from Patent EP1572962.
JD445815 - Sequence 426839 from Patent EP1572962.
JD383388 - Sequence 364412 from Patent EP1572962.
JD372676 - Sequence 353700 from Patent EP1572962.
JD428504 - Sequence 409528 from Patent EP1572962.
JD035630 - Sequence 16654 from Patent EP1572962.
JD021613 - Sequence 2637 from Patent EP1572962.
JD025789 - Sequence 6813 from Patent EP1572962.
JD030422 - Sequence 11446 from Patent EP1572962.
AK308597 - Homo sapiens cDNA, FLJ98638.
JD466106 - Sequence 447130 from Patent EP1572962.
JD071818 - Sequence 52842 from Patent EP1572962.
JD408529 - Sequence 389553 from Patent EP1572962.
JD336839 - Sequence 317863 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B1AK98, ENST00000372257.1, ENST00000372257.2, ENST00000372257.3, ENST00000372257.4, ENST00000372257.5, ENST00000372257.6, ERI3_HUMAN, NM_024066, O43414, PINT1, PRNPIP, PRNPIP1, Q5T2T7, Q5T2T9, Q5TG35, Q9BQA0, Q9UEB4, uc001clt.1, uc001clt.2, uc001clt.3, uc001clt.4, uc001clt.5
UCSC ID: ENST00000372257.7
RefSeq Accession: NM_024066
Protein: O43414 (aka ERI3_HUMAN)
CCDS: CCDS30696.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.