Human Gene ERI3 (ENST00000372259.9) from GENCODE V38
Description: Binds 2 magnesium ions per subunit (By similarity). (from UniProt O43414)
Gencode Transcript: ENST00000372259.9
Gencode Gene: ENSG00000117419.16
Transcript (Including UTRs)
Position: hg38 chr1:44,221,070-44,323,043 Size: 101,974 Total Exon Count: 7 Strand: -
Position: hg38 chr1:44,221,558-44,322,868 Size: 101,311 Coding Exon Count: 7
Data last updated at UCSC: 2021-09-27 09:51:20
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=ERI1 exoribonuclease 3; EC=3.1.-.-; AltName: Full=Prion interactor 1; AltName: Full=Prion protein-interacting protein;
COFACTOR: Binds 2 magnesium ions per subunit (By similarity). SUBUNIT: Interacts with PRNP (By similarity). SIMILARITY: Contains 1 exonuclease domain. SEQUENCE CAUTION: Sequence=AAC19158.1; Type=Erroneous initiation;
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR006055 - Exonuclease
IPR013520 - Exonuclease_RNaseT/DNA_pol3
IPR012337 - RNaseH-like_dom
Pfam Domains: PF00929 - Exonuclease
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on O43414
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AF007157 - Homo sapiens clone 23856 unknown mRNA, partial cds. BC144384 - Homo sapiens cDNA clone IMAGE:9052905. AK026596 - Homo sapiens cDNA: FLJ22943 fis, clone KAT08662, highly similar to AF007157 Homo sapiens clone 23856 unknown mRNA. BC001072 - Homo sapiens exoribonuclease 3, mRNA (cDNA clone IMAGE:2819900), complete cds. BC004456 - Homo sapiens exoribonuclease 3, mRNA (cDNA clone IMAGE:2819900), complete cds. AK293833 - Homo sapiens cDNA FLJ60449 complete cds, highly similar to Homo sapiens prion protein interacting protein (PRNPIP), mRNA. AK297708 - Homo sapiens cDNA FLJ56336 complete cds, highly similar to Homo sapiens prion protein interacting protein (PRNPIP), mRNA. AK290567 - Homo sapiens cDNA FLJ77066 complete cds, highly similar to Homo sapiens prion protein interacting protein (PRNPIP), mRNA. KJ903138 - Synthetic construct Homo sapiens clone ccsbBroadEn_12532 ERI3 gene, encodes complete protein. BC156812 - Synthetic construct Homo sapiens clone IMAGE:100062500, MGC:190531 exoribonuclease 3 (ERI3) mRNA, encodes complete protein. AB528814 - Synthetic construct DNA, clone: pF1KE0284, Homo sapiens PRNPIP gene for exoribonuclease 3, without stop codon, in Flexi system. JD037157 - Sequence 18181 from Patent EP1572962. JD389181 - Sequence 370205 from Patent EP1572962. JD243555 - Sequence 224579 from Patent EP1572962. JD191105 - Sequence 172129 from Patent EP1572962. JD023035 - Sequence 4059 from Patent EP1572962. JD031114 - Sequence 12138 from Patent EP1572962. JD445815 - Sequence 426839 from Patent EP1572962. JD383388 - Sequence 364412 from Patent EP1572962. JD372676 - Sequence 353700 from Patent EP1572962. JD428504 - Sequence 409528 from Patent EP1572962. JD035630 - Sequence 16654 from Patent EP1572962. JD021613 - Sequence 2637 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: AF007157, B1AK98, ENST00000372259.1, ENST00000372259.2, ENST00000372259.3, ENST00000372259.4, ENST00000372259.5, ENST00000372259.6, ENST00000372259.7, ENST00000372259.8, ERI3_HUMAN, O43414, PINT1, PRNPIP, PRNPIP1, Q5T2T7, Q5T2T9, Q5TG35, Q9BQA0, Q9UEB4, uc057ftu.1 UCSC ID: ENST00000372259.9 RefSeq Accession: NM_001301701
(aka ERI3_HUMAN) O43414
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.