Human Gene HIVEP3 (ENST00000372584.5) from GENCODE V38
  Description: Homo sapiens HIVEP zinc finger 3 (HIVEP3), transcript variant 2, mRNA. (from RefSeq NM_001127714)
RefSeq Summary (NM_001127714): This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011].
Gencode Transcript: ENST00000372584.5
Gencode Gene: ENSG00000127124.16
Transcript (Including UTRs)
   Position: hg38 chr1:41,506,365-41,918,707 Size: 412,343 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg38 chr1:41,510,451-41,584,797 Size: 74,347 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2021-09-27 09:51:20

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:41,506,365-41,918,707)mRNA (may differ from genome)Protein (2405 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transcription factor HIVEP3; AltName: Full=Human immunodeficiency virus type I enhancer-binding protein 3; AltName: Full=Kappa-B and V(D)J recombination signal sequences-binding protein; AltName: Full=Kappa-binding protein 1; Short=KBP-1; AltName: Full=Zinc finger protein ZAS3;
FUNCTION: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down- regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.
SUBUNIT: Interacts with TRAF1 AND TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
INDUCTION: By 12-O-tetradecanoylphorbol-13 acetate (TPA).
DOMAIN: The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures (By similarity).
PTM: Phosphorylated on threonine and serine residues (By similarity).
SIMILARITY: Contains 5 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAB13381.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.52 RPKM in Brain - Cerebellum
Total median expression: 58.16 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -349.301015-0.344 Picture PostScript Text
3' UTR -1381.604086-0.338 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q5T1R4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007275 multicellular organism development
GO:0035914 skeletal muscle cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  BC046120 - Homo sapiens, clone IMAGE:5178133, mRNA.
AF278765 - Homo sapiens kappa B and V(D)J recombination signal sequences binding protein (KRC) mRNA, complete cds.
BC152563 - Homo sapiens human immunodeficiency virus type I enhancer binding protein 3, mRNA (cDNA clone MGC:167844 IMAGE:8860523), complete cds.
AB046775 - Homo sapiens KIAA1555 mRNA for KIAA1555 protein.
AK122991 - Homo sapiens cDNA FLJ16752 fis, clone BRACE2013010, highly similar to Homo sapiens human immunodeficiency virus type I enhancer binding protein 3 (HIVEP3), mRNA.
BC172754 - Synthetic construct Homo sapiens clone IMAGE:9095599; MGC:199459 human immunodeficiency virus type I enhancer binding protein 3 (HIVEP3) gene, encodes complete protein.
AB385480 - Synthetic construct DNA, clone: pF1KA1555, Homo sapiens HIVEP3 gene for human immunodeficiency virus type I enhancer binding protein 3, complete cds, without stop codon, in Flexi system.
BC080552 - Homo sapiens cDNA clone IMAGE:6254031.
JD186424 - Sequence 167448 from Patent EP1572962.
JD474415 - Sequence 455439 from Patent EP1572962.
JD382615 - Sequence 363639 from Patent EP1572962.
JD489927 - Sequence 470951 from Patent EP1572962.
JD416034 - Sequence 397058 from Patent EP1572962.
JD055536 - Sequence 36560 from Patent EP1572962.
JD253441 - Sequence 234465 from Patent EP1572962.
JD511048 - Sequence 492072 from Patent EP1572962.
JD252225 - Sequence 233249 from Patent EP1572962.
JD166907 - Sequence 147931 from Patent EP1572962.
JD382906 - Sequence 363930 from Patent EP1572962.
JD095475 - Sequence 76499 from Patent EP1572962.
M61743 - Human kappa binding protein-1 (KBP-1) mRNA, partial cds.
JD487303 - Sequence 468327 from Patent EP1572962.
JD133948 - Sequence 114972 from Patent EP1572962.
JD437774 - Sequence 418798 from Patent EP1572962.
JD275597 - Sequence 256621 from Patent EP1572962.
JD415322 - Sequence 396346 from Patent EP1572962.
JD438700 - Sequence 419724 from Patent EP1572962.
JD362972 - Sequence 343996 from Patent EP1572962.
JD215350 - Sequence 196374 from Patent EP1572962.
JD262431 - Sequence 243455 from Patent EP1572962.
JD058577 - Sequence 39601 from Patent EP1572962.
JD492925 - Sequence 473949 from Patent EP1572962.
JD140041 - Sequence 121065 from Patent EP1572962.
BC040942 - Homo sapiens, clone IMAGE:5180231, mRNA.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5T1R4 (Reactome details) participates in the following event(s):

R-HSA-9008036 RUNX2 binds to HIVEP3 and WWP1
R-HSA-9008076 WWP1 polyubiquitinates RUNX2
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A7YY91, ENST00000372584.1, ENST00000372584.2, ENST00000372584.3, ENST00000372584.4, KBP1, KIAA1555, KRC, NM_001127714, Q5T1R4, Q5T1R5, Q9BZS0, Q9HCL7, uc001cha.1, uc001cha.2, uc001cha.3, uc001cha.4, uc001cha.5, ZAS3, ZEP3_HUMAN
UCSC ID: ENST00000372584.5
RefSeq Accession: NM_001127714
Protein: Q5T1R4 (aka ZEP3_HUMAN)
CCDS: CCDS463.1, CCDS44124.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.