Human Gene ARSH (ENST00000381130.3) from GENCODE V38
Description: Homo sapiens arylsulfatase family member H (ARSH), mRNA. (from RefSeq NM_001011719) RefSeq Summary (NM_001011719): Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381130.3/ ENSP00000370522.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gencode Transcript: ENST00000381130.3 Gencode Gene: ENSG00000205667.3 Transcript (Including UTRs) Position: hg38 chrX:3,006,546-3,034,111 Size: 27,566 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chrX:3,006,613-3,033,385 Size: 26,773 Coding Exon Count: 9
ID:ARSH_HUMAN DESCRIPTION: RecName: Full=Arylsulfatase H; Short=ASH; EC=3.1.6.-; COFACTOR: Binds 1 calcium ion per subunit (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). PTM: The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity). SIMILARITY: Belongs to the sulfatase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5FYA8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.