S. cerevisiae Gene ATG15 (YCR068W) Description and Page Index
  Description: Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
Transcript (Including UTRs)
   Position: sacCer3 chrIII:237,214-238,776 Size: 1,563 Total Exon Count: 1 Strand: +
Coding Region
   Position: sacCer3 chrIII:237,214-238,776 Size: 1,563 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated: 2011-08-29

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrIII:237,214-238,776)mRNAProtein (520 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ATG15_YEAST
DESCRIPTION: RecName: Full=Putative lipase ATG15; EC=3.1.1.3; AltName: Full=Autophagy-related protein 15; AltName: Full=Cytoplasm to vacuole targeting protein 17;
FUNCTION: Essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles.
CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
PTM: Glycosylated.
MISCELLANEOUS: Present with 3060 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002921 - Lipase_3

Pfam Domains:
PF01764 - Lipase (class 3)

ModBase Predicted Comparative 3D Structure on P25641
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004620 phospholipase activity
GO:0004806 triglyceride lipase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006624 vacuolar protein processing
GO:0006629 lipid metabolic process
GO:0006660 phosphatidylserine catabolic process
GO:0006914 autophagy
GO:0016042 lipid catabolic process
GO:0030397 membrane disassembly
GO:0034496 multivesicular body membrane disassembly
GO:0034727 piecemeal microautophagy of nucleus
GO:0046461 neutral lipid catabolic process

Cellular Component:
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005775 vacuolar lumen
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
GO:0032585 multivesicular body membrane


-  Other Names for This Gene
  UCSC ID: YCR068W
Protein: P25641 (aka ATG15_YEAST or AG15_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.