S. cerevisiae Gene RSA4 (YCR072C) Description and Page Index
  Description: WD-repeat protein involved in ribosome biogenesis may interact with ribosomes required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
Transcript (Including UTRs)
   Position: sacCer3 chrIII:240,805-242,352 Size: 1,548 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrIII:240,805-242,352 Size: 1,548 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrIII:240,805-242,352)mRNAProtein (515 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ribosome assembly protein 4;
FUNCTION: Involved in processing and efficient intra-nuclear transport or pre-60S ribosomal subunits. Forms a complex with REA1 which is essential for ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.
SUBUNIT: Associates with the pre-60S ribosomal particle. Interacts with MND1.
INTERACTION: Q12019:MDN1; NbExp=6; IntAct=EBI-21980, EBI-10633;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: Belongs to the NLE1/RSA4 family.
SIMILARITY: Contains 8 WD repeats.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020472 - G-protein_beta_WD-40_rep
IPR012972 - NLE
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF08154 - NLE (NUC135) domain
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on P25382
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
Genome BrowserNo orthologNo orthologNo orthologGenome BrowserGenome Browser
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