S. cerevisiae Gene EGD2 (YHR193C) Description and Page Index
  Description: Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
Transcript (Including UTRs)
   Position: sacCer3 chrVIII:487,712-488,236 Size: 525 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrVIII:487,712-488,236 Size: 525 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2011-08-29

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrVIII:487,712-488,236)mRNAProtein (174 aa)
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-  Comments and Description Text from UniProtKB
  ID: NACA_YEAST
DESCRIPTION: RecName: Full=Nascent polypeptide-associated complex subunit alpha; Short=NAC-alpha; AltName: Full=Alpha-NAC; AltName: Full=GAL4 DNA-binding enhancer protein 2;
FUNCTION: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 is also involved in transcription regulation.
SUBUNIT: Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and either EGD1 or BTT1. NAC associates with ribosomes via EGD1 or BTT1, and with the CCR4-NOT complex.
INTERACTION: Q02642:EGD1; NbExp=4; IntAct=EBI-6379, EBI-6371; P15731:UBC4; NbExp=2; IntAct=EBI-6379, EBI-19735;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus. Nuclear import may occur via redundant pathways including one requiring the karyopherins PSE1 and KAP123, which also participate in nuclear import of ribosomal subunits.
DOMAIN: The UBA domain is required for the stability of EGD1.
PTM: Ubiquitinated by the NOT4 E3 ligase and the UBC4 E2 ubiquitin conjugatin enzyme.
MISCELLANEOUS: Present with 38016 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the NAC-alpha family.
SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain.
SIMILARITY: Contains 1 UBA domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002715 - Nas_poly-pep-assoc_cplx
IPR016641 - Nas_poly-pep-assoc_cplx_asu
IPR000449 - UBA/transl_elong_EF1B_N

Pfam Domains:
PF01849 - NAC domain
PF00627 - UBA/TS-N domain

ModBase Predicted Comparative 3D Structure on P38879
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
Genome BrowserNo orthologGenome BrowserNo orthologGenome BrowserGenome Browser
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