J Virol 2000,
PMID: 10623769
Pereira, R A; Simon, M M; Simmons, A
Control of ganglionic herpes simplex virus (HSV) infection depends on CD8(+) cells but not on the death of infected neurons. Primarily, perforin and granzyme B mediate CD8(+) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown. Here, it is shown that granzyme A restricts the interneuronal spread of HSV and significantly influences ganglionic virus load.
Diseases/Pathways annotated by Medline MESH: Disease Models, Animal, Herpes Simplex
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Text Mining Data
CD8 → granzyme B: "
Primarily, perforin and
granzyme B mediate
CD8 ( + ) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown
"
Manually curated Databases
No curated data.