Gene interactions and pathways from curated databases and text-mining
J Virol 2000, PMID: 10623769

Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice.

Pereira, R A; Simon, M M; Simmons, A

Control of ganglionic herpes simplex virus (HSV) infection depends on CD8(+) cells but not on the death of infected neurons. Primarily, perforin and granzyme B mediate CD8(+) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown. Here, it is shown that granzyme A restricts the interneuronal spread of HSV and significantly influences ganglionic virus load.

Diseases/Pathways annotated by Medline MESH: Disease Models, Animal, Herpes Simplex
Document information provided by NCBI PubMed

Text Mining Data

CD8 → granzyme B: " Primarily, perforin and granzyme B mediate CD8 ( + ) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown "

Manually curated Databases

No curated data.