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AKAP-Lbc → LPA: " Notably, the activation of RhoA by cooperative LPA and integrin a ( 6 ) ß ( 4 ) signaling requires the Rho guanine nucleotide exchange factor AKAP-Lbc "
AKAP-Lbc → RhoA: " Notably, the activation of RhoA by cooperative LPA and integrin a ( 6 ) ß ( 4 ) signaling requires the Rho guanine nucleotide exchange factor AKAP-Lbc "
LPA → RhoA: " Notably, the activation of RhoA by cooperative LPA and integrin a ( 6 ) ß ( 4 ) signaling requires the Rho guanine nucleotide exchange factor AKAP-Lbc "
Rac1 → LPA: " We also determine that integrin a ( 6 ) ß ( 4 ) can not activate Rac1 directly but promotes LPA mediated Rac1 activation that is dependent on RhoA activity and de novo ß ( 1 ) integrin ligation "
RhoA → LPA: " Finally, we find that the regulation of Rac1 and RhoA in response to LPA is differentially regulated by phosphodiesterases, PKA, and phosphatidylinositol 3-kinase, thus supporting their spatially distinct compartmentalization "
RhoA → PKA: " Finally, we find that the regulation of Rac1 and RhoA in response to LPA is differentially regulated by phosphodiesterases, PKA , and phosphatidylinositol 3-kinase, thus supporting their spatially distinct compartmentalization "
Rac1 → LPA: " Finally, we find that the regulation of Rac1 and RhoA in response to LPA is differentially regulated by phosphodiesterases, PKA, and phosphatidylinositol 3-kinase, thus supporting their spatially distinct compartmentalization "
Rac1 → PKA: " Finally, we find that the regulation of Rac1 and RhoA in response to LPA is differentially regulated by phosphodiesterases, PKA , and phosphatidylinositol 3-kinase, thus supporting their spatially distinct compartmentalization "