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NOS3 — PPP2CA
Text-mined interactions from Literome
Greif et al., Biochemistry 2002
:
An inhibitor of
PP2A increases eNOS enzymatic activity and
augments overall levels of
eNOS phosphorylation, specifically increasing phosphorylation of serines 116 and 1179
Ramesh et al., J Clin Invest 2011
(Thrombosis) :
The inhibition of eNOS was caused by antibody recognition of domain I of ß2GPI and ß2GPI dimerization, and it was due to attenuated
eNOS S1179 phosphorylation
mediated by protein
phosphatase 2A (PP2A)
Zhang et al., Diabetes 2012
(Hypertension...) :
PP2A attenuates
eNOS phosphorylation by preventing phosphorylation of the pool of Akt that colocalizes with eNOS and by dephosphorylating eNOS ... We conclude that ceramide mediates obesity related vascular dysfunction by a mechanism that involves
PP2A mediated disruption of the
eNOS/Akt/Hsp90 signaling complex