Perino et al., Biochem Soc Trans 2006
:
In this complex, PI3Kgamma could regulate PDE3B activity through protein kinase A, a PDE activator
Guo et al., Endocr Res 2009
:
These findings suggest that apelin exerts direct inhibitory actions on the pancreatic beta-cells by activating PI3-kinase dependent PDE3B and subsequently suppressing of cAMP levels