Gene interactions and pathways from curated databases and text-mining

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BCR — IL6

Text-mined interactions from Literome

Hillion et al., J Immunol 2007 : Coordinated engagement of the BCR and CD40 promoted the synthesis of IL-6 and, thereby, up-regulation of its receptor on activated B lymphocytes
Reynaud et al., Cancer Cell 2011 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : We show that BCR/ABL activity controls Il-6 expression thereby establishing a paracrine feedback loop that sustains CML development
Matsuguchi et al., J Biol Chem 1994 (Leukemia, Megakaryoblastic, Acute) : Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor, interleukin-3 , and steel factor and is constitutively increased by p210BCR/ABL