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NFKB1 — PHKA2
Text-mined interactions from Literome
Shi et al., J Biol Chem 2001
:
Placing PYK2 upstream of both PI3K and Akt activation, PYK2 activated Akt through a PI3K dependent pathway, and either a dominant negative form of Akt or the PI3K inhibitor LY294002 blocked
PYK2 stimulated
NF-kappa B-dependent transcription
Anand et al., Mol Immunol 2009
(MAP Kinase Signaling System...) :
Inhibition of
Pyk2 activity using a pharmacological inhibitor, Tyrphostin A9 significantly
attenuated LPS induced Pyk2 tyrosine phosphorylation, p38 MAP kinase ( MAPK ) activation,
NF-kappaB activation, and MCP-1 expression