Block et al., J Biol Chem 2007
:
Down-regulation of Nox1, Nox4, and p22phox expression by small interfering RNA also decreased HIF-2alpha protein expression and inhibited Akt and 4E-BP1 phosphorylation, suggesting that a translational mechanism is involved in maintaining HIF-2alpha in VHL-deficient cells
Toschi et al., J Biol Chem 2008
:
Interestingly, the expression of HIF2 alpha was dependent on Akt2 , whereas that of HIF1 alpha was dependent on Akt3