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BCL2 — EPO
Text-mined interactions from Literome
Sola et al., Pediatr Res 2005
(Brain Ischemia...) :
The most effective dose after FCI was 1000 U/kg for 3 d. Immunoanalyses showed that
Epo induced a significant increase in phosphorylated Janus kinase 2 and signal transducer and activator of transcription-5 expressions at 1 and 3 d and up-regulated
Bcl-xL expression by 24 h after FCI but did not affect Epo receptor or NF-kappaB expression
Diwan et al., Apoptosis 2008
(Anemia...) :
Previously, we found that BH3-only proapoptotic factor, Nix, opposed erythroblast-survival signaling by
erythropoietin induced
Bcl-xl during normal erythrocyte formation
Okazaki et al., Neoplasia (New York, N.Y.) 2008
(Neovascularization, Pathologic) :
Erythropoietin activated the extracellular signal regulated kinase signaling pathway and up-regulated the expression of the downstream antiapoptotic protein
Bcl-xL in HMVECs
Liu et al., Clin Exp Pharmacol Physiol 2010
:
Furthermore,
EPO significantly
increased the expression of
Bcl-2 protein and the relative Bcl-2/Bax ratio, and decreased the activation of caspase 3 and formation of the p17 and p12 cleavage in similar conditions
Cassis et al., Kidney Int 2012
(Anemia...) :
Inhibition of p-Akt by Wortmannin partially antagonized the effect of EPO on allograft injury and tubular apoptosis, and prevented
EPO induced
Bcl-2 upregulation