Benus et al., Mol Biol Cell 2005
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IL-1beta and its downstream mediator TAK1 inhibit SMAD3 mediated TGFbeta target gene activation, whereas SMAD3 nuclear translocation and DNA binding in response to TGFbeta are not affected Gingery et al., Exp Cell Res 2008
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TAK1/MEK activation induces pro-survival BclX ( L ) expression and TAK1/MEK and SMAD pathway activation induces pro-survival Mcl-1 expression