◀ Back to GSK3B
AXIN1 — GSK3B
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CTNNB1
→
Complex of AXIN1-GSK3B
(directlyDecreases, AXIN1/GSK3B Activity)
Evidence: This binding induces a conformational change in the complex, resulting in the inhibition of GSK3beta phosphorylation of beta -catenin
-
BioCarta multi-step regulation of transcription by pitx2:
AXIN/APC/beta-catenin complex (AXIN1-PROC-CTNNB1)
→
GSK3-beta (GSK3B)
(modification, collaborate)
-
BioCarta multi-step regulation of transcription by pitx2:
GSK3-beta (GSK3B)
→
AXIN (AXIN1)
(modification, activates)
-
BioCarta multi-step regulation of transcription by pitx2:
AXIN/APC/beta-catenin complex (AXIN1-PROC-CTNNB1)
→
GSK3-beta (GSK3B)
(modification, collaborate)
-
BioCarta multi-step regulation of transcription by pitx2:
GSK3-beta (GSK3B)
→
AXIN (AXIN1)
(modification, activates)
-
KEGG Wnt signaling pathway:
AXIN1/AXIN2
→
GSK3B
(protein-protein, binding/association)
-
KEGG Endometrial cancer:
Complex of APC-APC2-AXIN1-AXIN2-GSK3B
→
CTNNB1
(protein-protein, missing interaction)
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2)
→
Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Zeng et al., Nature 2005, Bilic et al., Science 2007, Zeng et al., Development 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Degradation of beta catenin:
Axin1/APC//beta catenin/GSK3 complex (AXIN1-APC-CTNNB1-GSK3B_GSK3A)
→
GSK3 (GSK3B/GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Degradation of beta catenin:
Axin1/APC//beta catenin/GSK3 complex (AXIN1-APC-CTNNB1-GSK3B_GSK3A)
→
Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Degradation of beta catenin:
GSK3 (GSK3B/GSK3A)
→
Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
APC (APC)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
APC (APC)
→
WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
→
WNT3A/LRP6/FZD5 complex (WNT3A-LRP6-FZD5)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
→
WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5 complex (WNT3A-LRP6-FZD5)
→
WNT3A/LRP6/FZD5/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Degradation of beta catenin:
CK1 epsilon-CK1 delta-CK1 alpha (CSNK1E/CSNK1A1/CSNK1D)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, activates)
Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
PP2A B56alpha (PPP2R5A)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, activates)
Staal et al., EMBO Rep 2002, Zhang et al., J Biol Chem 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Staal et al., EMBO Rep 2002, Zhang et al., J Biol Chem 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
Gsk3beta (GSK3B)
→
Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1)
(modification, activates)
Ha et al., Mol Cell 2004
Evidence: assay, other species
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
Gsk3beta (GSK3B)
→
Axin1 (AXIN1)
(modification, activates)
Ha et al., Mol Cell 2004
Evidence: assay, other species
-
NCI Pathway Database Degradation of beta catenin:
APC/beta catenin complex (APC-CTNNB1)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Yamamoto et al., J Biol Chem 1999, Willert et al., Genes Dev 1999, Farr et al., J Cell Biol 2000, van Noort et al., J Biol Chem 2002, Dajani et al., EMBO J 2003, Ha et al., Mol Cell 2004, Liu et al., Curr Biol 2005, Su et al., Mol Cell 2008
Evidence: assay
-
NCI Pathway Database Degradation of beta catenin:
APC/beta catenin complex (APC-CTNNB1)
→
Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Yamamoto et al., J Biol Chem 1999, Willert et al., Genes Dev 1999, Farr et al., J Cell Biol 2000, van Noort et al., J Biol Chem 2002, Dajani et al., EMBO J 2003, Ha et al., Mol Cell 2004, Liu et al., Curr Biol 2005, Su et al., Mol Cell 2008
Evidence: assay
-
NCI Pathway Database Degradation of beta catenin:
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
→
Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Yamamoto et al., J Biol Chem 1999, Willert et al., Genes Dev 1999, Farr et al., J Cell Biol 2000, van Noort et al., J Biol Chem 2002, Dajani et al., EMBO J 2003, Ha et al., Mol Cell 2004, Liu et al., Curr Biol 2005, Su et al., Mol Cell 2008
Evidence: assay
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2)
→
Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/GSK3 complex (AXIN1-GSK3B_GSK3A)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
Evidence: assay, physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
APC (APC)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
APC (APC)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
APC (APC)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
CK1 gamma (CSNK1G1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, activates)
Davidson et al., Nature 2005, Zeng et al., Nature 2005, Zeng et al., Development 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
Gsk3beta (GSK3B)
→
Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1)
(modification, activates)
Dajani et al., EMBO J 2003
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
Gsk3beta (GSK3B)
→
Axin1 (AXIN1)
(modification, activates)
Dajani et al., EMBO J 2003
-
NCI Pathway Database Canonical Wnt signaling pathway:
CK1 gamma (CSNK1G1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, activates)
Zeng et al., Nature 2005, Piao et al., PloS one 2008, Yum et al., Biochem Biophys Res Commun 2009
Evidence: assay, physical interaction
-
NCI Pathway Database C-MYC pathway:
Axin1/GSK3beta/PIN1/PP2A-B56alpha complex (AXIN1-GSK3B-PIN1-PPP2CA-PPP2R5A)
→
MYC/Max complex (MYC-MAX)
(modification, activates)
Sears et al., Genes Dev 2000, Gregory et al., J Biol Chem 2003, Yeh et al., Nat Cell Biol 2004, Arnold et al., Mol Cell Biol 2006, Arnold et al., EMBO J 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Degradation of beta catenin:
Axin1/APC//beta catenin/GSK3 complex (AXIN1-APC-CTNNB1-GSK3B_GSK3A)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
Evidence: assay
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
APC (APC)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
APC (APC)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
Reactome Reaction:
AXIN1
→
GSK3B
(reaction)
Seeling et al., Science 1999, Yamamoto et al., J Biol Chem 1999, Willert et al., Genes Dev 1999, Jho et al., Biochem Biophys Res Commun 1999, Liu et al., Cell 2002, Amit et al., Genes Dev 2002, Dajani et al., EMBO J 2003, Tamai et al., Mol Cell 2004, He et al., Development 2004, Zeng et al., Nature 2005, Liu et al., J Mol Biol 2006, Luo et al., EMBO J 2007, Major et al., Science 2007, MacDonald et al., J Biol Chem 2008, Hanaki et al., Mol Cancer Ther 2012, Saito-Diaz et al., Growth Factors 2013, Kim et al., Science 2013, Ikeda et al., EMBO J 1998
-
Reactome Reaction:
AXIN1
→
GSK3B
(direct_complex)
Seeling et al., Science 1999, Yamamoto et al., J Biol Chem 1999, Willert et al., Genes Dev 1999, Jho et al., Biochem Biophys Res Commun 1999, Dajani et al., EMBO J 2003, Xing et al., Mol Cell 2004, Liu et al., J Mol Biol 2006, Luo et al., EMBO J 2007, Major et al., Science 2007, Hanaki et al., Mol Cancer Ther 2012, Saito-Diaz et al., Growth Factors 2013, Kim et al., Science 2013, Ikeda et al., EMBO J 1998
-
WikiPathways Neural Crest Differentiation:
AXIN2/AXIN1
→
GSK3B
(mim-necessary-stimulation)
-
WikiPathways Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds:
DVL2
→
Complex of AXIN1-TNKS-GSK3B-APC-CSNK1A1-CTNNB1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Zhou et al., Biochim Biophys Acta 2012*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(direct interaction, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Varjosalo et al., Nat Methods 2013
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Yamamoto et al., Dev Cell 2006
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Fei et al., Mol Cell Biol 2013*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(direct interaction, two hybrid)
Nakamura et al., Genes Cells 1998*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Nakamura et al., Genes Cells 1998*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(direct interaction, pull down)
Nakamura et al., Genes Cells 1998*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Mak et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Hino et al., Mol Cell Biol 2005*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Kim et al., FASEB J 2008*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Yan et al., J Biol Chem 2012*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Kitagawa et al., EMBO J 1999
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Arnold et al., EMBO J 2009
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Cha et al., Oncogene 2011*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(direct interaction, pull down)
Cha et al., Oncogene 2011*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Kashikar et al., Cell cycle (Georgetown, Tex.) 2011*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Zhang et al., PloS one 2012*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Sue Ng et al., Biol Chem 2010
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Kim et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Tang et al., J Biol Chem 2008*
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Li et al., Cell 2012
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Luo et al., EMBO J 2007
-
IRef Biogrid Interaction:
GSK3B
—
AXIN1
(physical association, affinity chromatography technology)
Rosanò et al., Proc Natl Acad Sci U S A 2009*
-
MIPS CORUM Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex:
Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex complex (AXIN1-CTNNB1-GSK3B-PPP2R5A)
Gao et al., Proc Natl Acad Sci U S A 2002
-
MIPS CORUM AXIN-APC-betaCatenin-GSK3B complex:
AXIN-APC-betaCatenin-GSK3B complex complex (APC-AXIN1-CTNNB1-GSK3B)
Hinoi et al., J Biol Chem 2000*
-
IRef Corum Interaction:
Complex of PPP2R5A-GSK3B-AXIN1-CTNNB1
(association, anti tag coimmunoprecipitation)
Gao et al., Proc Natl Acad Sci U S A 2002
-
IRef Dip Interaction:
GSK3B
—
AXIN1
(physical association, anti bait coimmunoprecipitation)
Rosanò et al., Proc Natl Acad Sci U S A 2009*
-
IRef Dip Interaction:
GSK3B
—
AXIN1
(physical association, anti bait coimmunoprecipitation)
Huang et al., Nature 2009
-
Gene Ontology Complexes beta-catenin destruction complex:
beta-catenin destruction complex complex (AXIN1-GSK3A-GSK3B-CTNNB1-CTNNBIP1-DACT1)
Penman et al., J Cell Sci 2005, Rayasam et al., Br J Pharmacol 2009, Huang et al., Nature 2009, Yuan et al., PloS one 2012, Rubinfeld et al., Science 1996, Hart et al., Curr Biol 1998
-
Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
-
IRef Intact Interaction:
Complex of DVL3-GSK3B-AXIN1-APC
(association, anti bait coimmunoprecipitation)
Li et al., Cell 2012
-
IRef Intact Interaction:
Complex of GSK3B-AXIN1-PRMT1-CTNNB1
(association, anti bait coimmunoprecipitation)
Cha et al., Oncogene 2011*
-
IRef Intact Interaction:
Complex of GSK3B-AXIN1-CTNNB1-AMER1-APC
(association, anti bait coimmunoprecipitation)
Li et al., Cell 2012
-
IRef Intact Interaction:
Complex of GSK3B-AXIN1-CTNNB1-FBXW11-GSK3B-AXIN1-CTNNB1-FBXW11
(association, anti bait coimmunoprecipitation)
Li et al., Cell 2012
-
IRef Intact Interaction:
Complex of 16 proteins
(association, anti bait coimmunoprecipitation)
Li et al., Cell 2012
-
IRef Intact Interaction:
Complex of 19 proteins
(association, anti bait coimmunoprecipitation)
Li et al., Cell 2012
-
IRef Intact Interaction:
Complex of 12 proteins
(association, tandem affinity purification)
Varjosalo et al., Cell reports 2013
-
IRef Intact Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Varjosalo et al., Nat Methods 2013
-
IRef Intact Interaction:
Complex of 120 proteins
(association, anti bait coimmunoprecipitation)
Brazão et al., FEBS Lett 2012
-
IRef Intact Interaction:
Complex of AXIN1-GSK3B-CTNNB1
(association, anti tag coimmunoprecipitation)
Kim et al., EMBO J 2012*
-
IRef Intact Interaction:
Complex of 25 proteins
(association, anti bait coimmunoprecipitation)
Li et al., Cell 2012
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti tag coimmunoprecipitation)
Arnold et al., EMBO J 2009
-
IRef Intact Interaction:
Complex of AXIN1-GSK3B-AXIN1-GSK3B
(phosphorylation reaction, protein kinase assay)
Mao et al., Cell 2009*
-
IRef Intact Interaction:
Complex of MYC-GSK3B-AXIN1-PPP2CA
(association, anti tag coimmunoprecipitation)
Arnold et al., EMBO J 2009
-
IRef Intact Interaction:
GSK3B
—
AXIN1
(phosphorylation reaction, protein kinase assay)
Mao et al., Cell 2009*
-
IRef Intact Interaction:
GSK3B
—
AXIN1
(physical association, anti bait coimmunoprecipitation)
Coluccia et al., EMBO J 2007
-
IRef Intact Interaction:
GSK3B
—
AXIN1
(direct interaction, pull down)
Oosterveen et al., Dev Biol 2007*
-
IRef Intact Interaction:
GSK3B
—
AXIN1
(physical association, anti bait coimmunoprecipitation)
Huang et al., Nature 2009
-
IRef Intact Interaction:
GSK3B
—
AXIN1
(physical association, anti bait coimmunoprecipitation)
Cha et al., Oncogene 2011*
-
IRef Intact Interaction:
GSK3B
—
AXIN1
(physical association, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
GSK3B
—
AXIN1
(colocalization, confocal microscopy)
Wang et al., Molecular systems biology 2011
-
IRef Ophid Interaction:
GSK3B
—
AXIN1
(aggregation, confirmational text mining)
Kodama et al., J Biol Chem 1999
-
IRef Ophid Interaction:
GSK3B
—
AXIN1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Hedgepeth et al., Mol Cell Biol 1999
:
Similarly, mutants of
axin lacking key regulatory domains such as the RGS domain, which is required for interaction with the adenomatous polyposis coli protein, bind and
inhibit GSK-3beta in vivo, suggesting that these domains are critical for proper regulation of GSK-3beta activity ... We have identified a novel self-interaction domain in axin and have shown that formation of an
axin regulatory complex in vivo is
critical for axis formation and
GSK-3beta activity ... Based on these data, we propose that the
axin complex may directly
regulate GSK-3beta enzymatic activity in vivo
Kim et al., J Biol Chem 2003
:
Overexpression of
axin1 , a GSK3 beta regulated scaffolding protein, did not
affect the physical interaction between
GSK3 beta and MEKK1 in transfected HEK293 cells
Chen et al., J Biol Chem 2009
:
The Ser and Thr residues in the motif appear to be also phosphorylated by glycogen synthase kinase 3beta ( GSK3beta ) and the CKI family kinases, as
GSK3beta and CKIepsilon could
enhance the interaction of Zbed3 with
Axin