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GSK3B — TGFB1
Text-mined interactions from Literome
Yoshino et al., Biochem Biophys Res Commun 2007
(Fibrosis) :
TGF-beta1 increased the phosphorylated form of
GSK-3beta in HKC-8 cells, and inhibition of GSK-3beta by the selective inhibitors lithium and TDZD-8 caused Snail1 protein to accumulate
Caraci et al., Pharmacol Res 2008
:
TGF-beta1 also
increased the expression of the Ser-9 phosphorylated inactive form of
glycogen synthase kinase-3beta ( GSK-3beta ), an effect that was largely attenuated by PD98059
Clifford et al., J Biol Chem 2008
:
Novel
regulation of vascular endothelial growth factor-A ( VEGF-A ) by
transforming growth factor (beta)1 : requirement for Smads, ( beta)-CATENIN, AND
GSK3(beta)
Li et al., J Am Soc Nephrol 2009
(Disease Models, Animal...) :
Pharmacologic inhibition of ILK with small-molecule inhibitor QLT-0267 abolished
TGF-beta1 induced phosphorylation of Akt and
glycogen synthase kinase-3beta , suppressed cyclin D1 expression, and largely restored the expression of E-cadherin and zonula occludens 1
Deng et al., Am J Physiol Lung Cell Mol Physiol 2010
(Hypertension...) :
Unlike epidermal growth factor, BMP-4,
TGF-beta1 , 5-HT, and ET-1 each
increased smooth muscle cell size, contractile protein expression, fractional cell shortening, and
GSK-3beta phosphorylation ... Expression of a non-phosphorylatable
GSK-3beta mutant
blocked BMP-4-,
TGF-beta1- , 5-HT-, and ET-1 induced cell size enlargement, suggesting that GSK-3beta phosphorylation is required and sufficient for cellular hypertrophy
Hua et al., Eur J Pharmacol 2010
:
Glycogen synthase kinase-3beta negatively
regulates TGF-beta1 and Angiotensin II-mediated cellular activity through interaction with Smad3 ... These results uncovered a novel mechanism for the
GSK3beta negative
regulation of
TGF-beta1/Smad3 and Angiotensin II/Smad3 mediated transcription and apoptosis by the identification of a crosstalk between GSK3beta and Smad3 signal pathway