Muthukumarana et al., Transplantation 2007
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We compared the effect of wt-Foxp3 versus mutant DeltaE251-Foxp3, which lacks transcriptional activity, on transcript levels of axotrophin, LIF, and suppressor of cytokine signaling-3 ( SOCS-3 ; a feedback inhibitor of LIF ) in the Jurkat human T-cell line
Knosp et al., J Immunol 2013
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In this study, we show that despite having no effect on natural Treg development or function, SOCS2 is highly expressed in iTregs and required for the stable expression of Foxp3 in iTregs in vitro and in vivo