◀ Back to IFNG
IFNG — SEA
Text-mined interactions from Literome
Montenegro et al., J Infect Dis 1999
(Acute Disease...) :
Neutralization of IL-10 had no effect on the
SEA-specific IFN-gamma response in patients with acute infection, whereas SWAP induced IFN-gamma was increased in both groups
Farah et al., Scand J Immunol 2000
(Granuloma...) :
Group A animals had higher levels of
SEA induced
interferon-gamma (IFN-gamma) but lower levels of interleukin (IL)-5 than groups B and C ( P < 0.01 ) ... Group B animals had low
SEA induced
IFN-gamma levels and elevated IL-5 levels, although these were lower than group C. SEA induced IL-10 was low in both groups A and B as compared to group C ( P < 0.01 )
Hegardt et al., Cell Immunol 2000
(Disease Progression...) :
Plastic adherent spleen cells from tumor bearing rats suppressed the
SEA induced proliferative response and the production of
IFN-gamma and IL-10 by nonadherent spleen cells from tumor-free rats
King et al., Parasite Immunol 2001
(Schistosomiasis mansoni) :
By contrast, CD4+ splenocytes produced comparatively little cytokine release by endogenous antigen, whereas exogenous
SEA strongly
induced IL-4, IL-5, IL-10 and
IFN-gamma production and lymphocyte proliferation that correlated poorly with the dynamics of granulomatous inflammation
Shen et al., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2000
(Recurrence...) :
IFN-gamma levels
induced by both
SEA and SWAP were increased significantly after praziquantel treatment
Pontzer et al., Proc Natl Acad Sci U S A 1992
(Burkitt Lymphoma) :
The peptide V beta 3- ( 57-77 ) also inhibited
SEA induced
interferon-gamma production and SEA induced proliferation of B10.BR spleen cells
Shen et al., Parasite Immunol 2003
(Schistosomiasis japonica) :
S. japonicum soluble worm antigen ( SWAP ) and
soluble egg antigen (SEA) stimulated IL-4, IL-5 and
IFN-gamma production in whole-blood cultures were measured by ELISA ... There was some indication that the risk of infection might be associated with gender ( with females being at higher risk ) and with the intensity of water contact, and there was evidence that levels of
SEA induced
IFN-gamma production were associated with reduced risk of infection
Muralimohan et al., Cell Immunol 2006
:
Further, even though
IFNgamma deficient pDCs were not
activated by
SEA , they were still capable of producing wild-type levels of IFNalpha in response to CpG oligodeoxynucleotide ( ODN )
Shen et al., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2007
(Schistosomiasis japonica) :
The level of
IFN-gamma in spleen cells from group A in
response to ConA and
SEA ( 171.2 and 70.8 pg/ml, respectively ) was higher than that of group D ( 91 and 49.7 pg/ml, respectively ) ( P < 0.01 )
Rutitzky et al., J Immunol 2008
(Liver Diseases, Parasitic...) :
We now show that mice lacking the IL-23-specific subunit p19 are impaired in developing severe immunopathology following immunization with SEA/CFA, which is associated with a marked drop of IL-17 in the granulomas, but not in the draining mesenteric lymph nodes, and with a markedly suppressed
SEA-specific IFN-gamma response regulated by a striking increase in IL-10
Da'dara et al., Vaccine 2010
(Schistosomiasis mansoni) :
However, we found that PZQ treatment significantly increased levels of
IFN-gamma in
response to concanavalin A or
SEA compared to splenocytes from untreated mice
Kato et al., Immunobiology 1990
:
In analyzing the phenomenon in vitro, we showed that
SEA induced
IFN-gamma in the supernatant of the spleen cell culture from BCG immunized B6 mice and that leukotriene C4 ( LTC4 ) from BCG activated macrophages in the spleen was involved in the IFN production from Ly 1+ T cells ... The result showed that the
SEA induced
IFN-gamma production was observed in spite of suppression of SEA induced IL-2 production in spleen cells from BCG immunized B6 mice
Tokman et al., J Interferon Res 1990
:
Staphylococcal enterotoxin A (SEA) induced the production of
interferon-gamma (IFN-gamma) by spleen cells from ICR Swiss mice during the first 24 h of culture
Pontzer et al., J Immunol 1989
:
SEA ( 1-27 ), but not SEA ( 28-45 ),
blocked proliferation of human peripheral T cells and induction of
IFN-gamma by the T cell line, L12-R4
Platsoucas et al., Cell Immunol 1986
:
Staphylococcal enterotoxin A (SEA) , a protein isolated from culture supernatants of Staphylococcus aureus, is a potent T-cell mitogen and an
inducer of
interferon-gamma (IFN-gamma)
Wilson et al., J Clin Invest 1986
:
Staphylococcal enterotoxin A (SEA) stimulated cord cell
IFN gamma production at low cell densities ; nevertheless, adult cells produced more IFN in response to SEA 1,341 +/- 350 U/ml ) than cord cells ( 350 +/- 33 U/ml )
Platsoucas et al., Scand J Immunol 1986
(Leukemia, Erythroblastic, Acute) :
A monoclonal antibody specific for human IFN-gamma blocked augmentation of NK by E. coli derived
IFN-gamma and natural IFN-gamma, but not by E. coli
derived IFN-alpha A or
staphylococcal enterotoxin A (SEA). ( ABSTRACT TRUNCATED AT 400 WORDS )
Jorizzo et al., Int J Dermatol 1985
(Candidiasis...) :
Oral ibuprofen failed to have any consistent effect during sequential 4-week on and off cycles on the following parameters : delayed hypersensitivity skin testing ; lymphocyte transformation to Candida antigen ; T-cell subsets as determined by monoclonal antibody techniques ; production of human
immune interferon in
response to
staphylococcal enterotoxin A (SEA)
Carlsson et al., Cell Immunol 1985
:
Histamine inhibited the production of
interferon-gamma and interleukin 2 (IL-2)
induced in human peripheral blood mononuclear cells by
Staphylococcal Enterotoxin A (SEA) but had no effect on the expression of IL-2 receptors
Archer et al., Immunopharmacology 1981
:
Staphylococcal enterotoxin A (SEA) is both a potent
inducer of
immune interferon ( IFN-gamma ) and suppressor of the murine primary in vitro plaque forming cell (PFC) response to the thymus dependent antigen sheep erythrocytes ( SRBC )
Yokomizo et al., J Vet Med Sci 1995
:
SEA , SEB, SEC and TSST-1, all
induced the in vitro release of interleukin-2,
interferon gamma and tumor necrosis factor alpha in a dose dependent manner
Blum et al., J Immunol 1993
(Schistosomiasis mansoni) :
SP enhances, whereas SOM inhibits
soluble egg Ag (SEA) induced ,
IFN-gamma production
König et al., Int Arch Allergy Immunol 1995
(Dermatitis, Atopic) :
In contrast to normal donors T cells from donors with AD predominantly express mRNA for IL-4, IL-5, and only diminished levels for
IFN-gamma and IL-12 upon
stimulation with SEB and
SEA
Srinivas et al., Scand J Immunol 1998
:
Stimulation of PBM by
SEA resulted in increased levels of IL-1beta, IL-2 and
interferon (IFN)-gamma after 24h
Nielsen et al., Tissue Antigens 1998
(Psoriasis) :
In contrast,
SEA with a mutation in the MHC class II alpha binding site
induces IFN-gamma and a qualitatively changed tyrosine phosphorylation profile