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PTGS2 — RNF19A
Text-mined interactions from Literome
McGinty et al., Biochem J 2000
:
Similarly, activation of JNK by Ad-MKK7D and
p38-MAPK by Ad-MKK3bE/Ad-MKK6bE
resulted in the increased expression of
PGHS-2
Kulkarni et al., Clin Cancer Res 2001
(Adenocarcinoma...) :
The induction of
COX-2 by EGF was
suppressed by inhibitors of tyrosine kinase activity, phosphatidylinositol 3-kinase, mitogen activated protein kinase kinase, and
p38 mitogen activated protein kinase ... Moreover, overexpressing dominant negative forms of extracellular signal regulated kinase 1, c-Jun NH2-terminal kinase,
p38 , and c-Jun
blocked EGF mediated induction of
COX-2 promoter activity
Kim et al., Dig Dis Sci 2001
:
An NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), a MAP kinase ( MEK ) inhibitor ( PD98059 ), and a
p38 MAP kinase inhibitor ( SB203580 ) significantly
suppressed the
COX-2 gene transcription and PGE2 synthesis in the neutrophils
Park et al., Mol Pharmacol 2002
:
Moreover, IL-1 beta stimulation of the cells caused the phosphorylation of
p38 and extracellular signal regulated kinase ( ERK ), and IL-1 beta induced
COX-2 expression was
inhibited by the pretreatment of WISH cells with a p38 inhibitor, in contrast ERK upstream inhibitor had no effect
Nagano et al., Int Immunol 2002
:
Taken together, these results suggest that both ERK and
p38 ( MAPK ) pathways are
involved in LPS induced
COX-2 expression and PGE ( 2 ) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Degousee et al., Circ Res 2003
(MAP Kinase Signaling System) :
These results provide direct evidence that MKK6 mediated
p38 MAPK activation is
necessary for interleukin-1beta induced cardiac myocyte
COX-2 gene expression and PGE2 biosynthesis in vitro and is sufficient for COX-2 gene expression by cardiac myocytes in vitro and in vivo
Ho et al., Br J Pharmacol 2004
(Inflammation) :
The selective
p38 MAPK inhibitor, SB203580,
inhibited the promoter activities of iNOS and
COX-2 rather than that of TNF-alpha
Yamaguchi et al., Arterioscler Thromb Vasc Biol 2004
(Diabetes Mellitus) :
PDGF-BB induced
p38 phosphorylation also
regulated cell growth,
cyclooxygenase-2 levels, and arachidonic acid release, but not apoptosis
Gutiérrez-Venegas et al., Life Sci 2005
:
However,
p38 inhibition only partially
blocked COX-2 expression and PGE2 synthesis
Kucknoor et al., Cell Microbiol 2005
:
Data suggest that
p38 mitogen activated protein ( MAP ) kinase and tyrosine kinases
play a role in
COX-2 induction
Jang et al., Free Radic Biol Med 2005
(MAP Kinase Signaling System) :
Pharmacologic inhibition of extracellular signal regulated kinase ( ERK ) and
p38 mitogen activated protein kinase ( p38 MAPK ) and dominant negative mutation of both enzymes
suppressed not only Abeta induced NF-kappaB transactivation but also
COX-2 expression and PGE ( 2 ) production
Shafer et al., Biochim Biophys Acta 2005
:
These results indicate that activation of
p38MAPK signaling is
sufficient for
COX-2 expression in IEC-18 cells
Ulivi et al., J Cell Biochem 2008
(Inflammation) :
p38/NF-kB dependent expression of
COX-2 during differentiation and inflammatory response of chondrocytes
Ulivi et al., J Cell Physiol 2008
(Inflammation) :
( 4 )
p38 is
involved in the PPARgamma mediated induction of
COX-2
Park et al., J Dent Res 2010
:
Studies on the intra-cellular signaling pathways revealed that
p38 activation is
required for the synergistic activation of
Cox-2 by TLR2 and histamine
Husvik et al., Eur J Oral Sci 2009
(Carcinoma, Squamous Cell...) :
Thus, JNK negatively regulated EGF induced extracellular signal regulated kinase 1/2 and/or
p38 mediated
COX-2 transcription, presumably through activating an unidentified phosphatase
Cho et al., Mol Immunol 2011
:
Pharmacologic inhibitors of ERK and
p38 mitogen activated protein kinases
inhibited the
COX-2 upregulation
Zhu et al., Acta Pharmacol Sin 2012
(MAP Kinase Signaling System) :
Aldosterone treatment significantly increased the expression of
Cox-2 and IL-6 and
activation of
p38MAPK and NF-?B
Guan et al., J Biol Chem 1998
:
We reported previously that IL-1beta rapidly activates the c-Jun NH2-terminal/stress activated protein kinases ( JNK/SAPK ) and
p38 mitogen activated protein kinase ( MAPK ) and also
induces Cox-2 expression and prostaglandin E2 ( PGE2 ) production
Dean et al., J Biol Chem 1999
:
p38 mitogen activated protein kinase
regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide treated human monocytes