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CYP19A1 — EGF
Text-mined interactions from Literome
Richards et al., J Steroid Biochem Mol Biol 2002
(Breast Neoplasms) :
The
effects of
epidermal growth factor (EGF) , transforming growth factor-beta ( TGFbeta ), and tetradecanoyl phorbol acetate ( TPA ) on
aromatase and COXs were studied in primary cultures of normal human adipose stromal cells and in cell cultures of normal immortalized human breast epithelial cells MCF-10F, estrogen-responsive human breast cancer cells MCF-7, and estrogen-unresponsive human breast cancer cells MDA-MB-231 ...
EGF and TPA in MCF-7 cells significantly
increased aromatase activity while TGFbeta did not ...
Aromatase enzyme activity in normal adipose stromal cells was significantly
increased by
EGF , TGFbeta and TPA after 24h of treatment
Ryde et al., Cancer Res 1992
(Breast Neoplasms) :
Aromatase activity in MCF7 cells was significantly
stimulated by phorbol 12,13-diacetate [ PDA ], dibutyryl cyclic AMP [ ( Bu ) 2cAMP ], transforming growth factor alpha, and
epidermal growth factor individually and PDA and ( Bu ) 2cAMP in combination, while it was inhibited by dexamethasone and unaffected by transforming growth factor beta, fibroblast growth factor, platelet derived growth factor, prolactin, and tamoxifen ...
Aromatase activity in T47D cells was
stimulated by transforming growth factor alpha,
epidermal growth factor , platelet derived growth factor, prolactin, dexamethasone, and cortisol individually and PDA and ( Bu ) 2cAMP in combination
Watanabe et al., J Endocrinol 2006
(Adrenal Cortex Neoplasms) :
Effect of
epidermal growth factor and prostaglandin on the expression of
aromatase ( CYP19 ) in human adrenocortical carcinoma cell line NCI-H295R cells ... We investigated the
effects of
epidermal growth factor (EGF) and prostaglandins ( PG ) on the expression of
aromatase ( CYP19 ) in human adrenocortical carcinoma cell line NCI-H295R cells ...
EGF significantly
increased aromatase activity and CYP19 gene transcript in NCI-H295R cells ... The results of experiments using protein kinase ( PK ) inhibitors suggest that the cAMP-PKA signaling pathway is involved in the
up-regulation of
aromatase expression by
EGF ... These results suggest that PGE ( 2 ) secondarily acts as an autocrine signal in the
up-regulation of
aromatase expression by
EGF in NCI-H295R cells
Emoto et al., Proc Soc Exp Biol Med 1991
:
Although basic fibroblast growth factor ( 1-100 ng/ml ), acidic fibroblast growth factor ( 1 ng/ml ),
epidermal growth factor ( 1 ng/ml ), platelet derived growth factor ( 1 ng/ml ), tumor necrosis factor ( 1 ng/ml ), and transforming growth factor-beta 1 ( 1 ng/ml ) have no
effect on basal
aromatase activity in human skin fibroblasts, all of these growth factors inhibited the ability of dibutyryladenosine 3',5'-cyclic monophosphate to stimulate aromatase activity
Bendell et al., Endocrinology 1990
:
As shown previously
EGF alone
had no effect on basal
aromatase activity ...
EGF however
inhibited FSH induced and FSH plus IGF-I induced
aromatase activity ... In this paper we show that
EGF also
inhibited the FSH induced
aromatase activity in the presence of TGF beta, which augmented FSH action on this system ... The action of EGF on 3 beta-hydroxysteroid dehydrogenase ( 3 beta-HSD ) was different from the
effect of
EGF on
aromatase ...
EGF can inhibit or
stimulate growth and differentiated functions (
aromatase and 3 beta-HSD ), the response depending on the context of the signals that the cell receives from its endocrine and microenvironment
Silva et al., Res Vet Sci 2013
:
The
effects of
epidermal growth factor (EGF) on the in vitro development of isolated goat secondary follicles and the relative mRNA expression of EGF, EGF-R, FSH-R and P450
aromatase in cultured follicles
Mendelson et al., Endocrinology 1986
:
Epidermal growth factor (EGF) , fibroblast growth factor ( FGF ), and platelet derived growth factor ( PDGF ) were all without effect on aromatase activity when added by themselves, but markedly
inhibited aromatase activity stimulated by ( Bu ) 2cAMP
Tseng et al., Endocrinology 1987
:
On the other hand, human CG,
epidermal growth factor , human PRL, and insulin did not
increase the
aromatase activity in the presence or absence of MPA and E2 studied in a limited number of specimens
Evans et al., J Biol Chem 1987
:
Effects of dibutyryl cyclic AMP,
epidermal growth factor , and phorbol esters on the synthesis of
aromatase cytochrome P-450
Dorrington et al., Steroids 1987
:
This study describes the
effects of insulin, insulin-like growth factor 1 (IGF1), and
epidermal growth factor (EGF) on the
aromatase activity of granulosa cells isolated from immature rat ovaries ...
EGF inhibited the actions of both FSH and insulin on
aromatase activity
Steinkampf et al., Mol Cell Endocrinol 1988
:
Effects of
epidermal growth factor and insulin-like growth factor I on the levels of mRNA encoding
aromatase cytochrome P-450 of human ovarian granulosa cells
James et al., Steroids 1987
(Breast Neoplasms) :
Studies in which we have examined the
effect of
epidermal growth factor on
aromatase activity in cultured breast adipose tissue suggests that the response may be influenced by a subject 's menopausal status
Schteingart et al., J Steroid Biochem Mol Biol 1995
:
Regulation of Sertoli cell
aromatase activity by cell density and prolonged stimulation with FSH,
EGF , insulin and IGF-I at different moments of pubertal development
McAllister et al., J Clin Endocrinol Metab 1994
:
In granulosa-lutein cells, forskolin stimulated
aromatase activity was
suppressed by
EGF , FGF, and TPA
Hurst et al., J Endocrinol Invest 1993
:
EGF may
mediate luteinized granulosa cell
aromatase activity in vivo, and may be a factor responsible for the relative decline in estrogen production in the preovulatory follicle
Hynes et al., J Reprod Fertil 1996
:
FSH and IGF-I, but not
EGF ,
stimulated ( P < 0.01 )
aromatase activity of granulosa cells