◀ Back to MAPK1

AREG — MAPK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK1 → AREG (increases) Shin et al., Circ Res 2003*
  Evidence: In contrast, AR, a specific ErbB1 ligand, induced sustained ERK1/2 and Elk1 phosphorylation, increased cyclin D1 mRNA and protein, and increased DNA synthesis activity.

Text-mined interactions from Literome

Kato et al., Biochem Biophys Res Commun 2003 (MAP Kinase Signaling System) : As evidenced by Western blot analysis, amphiregulin stimulated the phosphorylation of p42/p44-mitogen activated protein kinase ( MAPK ), p38-MAPK, c-Jun NH2-terminal protein kinase (JNK), and Akt/protein kinase B (PKB), respectively
Chung et al., Exp Cell Res 2005 (MAP Kinase Signaling System) : The morphological and biochemical effects of amphiregulin are prevented by EGF receptor blockade but require Src-family kinase activity and MAPK signaling
Shinohara et al., Gastroenterology 2010 : The transgenic mice were hypochloridric and had an increased number of Ki67- and proliferating cell nuclear antigen positive cells ; increased levels of plasma gastrin ; increased expression of transforming growth factor-a, amphiregulin , and gastrin ; and activation of extracellular signal regulated kinase 2