Gene interactions and pathways from curated databases and text-mining

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CRP — MAPK1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Westra et al., Ann Rheum Dis 2006 (Carcinoma, Hepatocellular...) : Production and mRNA expression of CRP and fibrinogen, but not SAA production and mRNA expression, were significantly inhibited by p38 MAPK specific inhibitor in hepatoma cell lines
Kawahara et al., Cardiovasc Pathol 2008 (Inflammation) : C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells
Kikuchi et al., Exp Lung Res 2009 : Taken together, these results suggest that the inhibitory effect of CRP is mediated by blocking MAPK