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CASP7 — EPHB2
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Han et al., J Neurosci 2000
(Hypoxia-Ischemia, Brain) :
Pharmacological inhibition of
ERK , but not the PI3-kinase pathway,
inhibited the ability of BDNF to block H-I induced
caspase-3 activation and tissue loss
Tashker et al., Mol Biol Cell 2002
:
Concomitantly, we have also demonstrated that recombinant Mos, MEK, and
ERK are
sufficient to block cytochrome c-dependent
caspase activation in purified Xenopus cytosol, which lacks both transcription and translation
Varghese et al., J Biol Chem 2002
:
Head involution defective ( Hid ) -triggered apoptosis requires
caspase-8 but not FADD ( Fas associated death domain ) and is
regulated by
Erk in mammalian cells
Rabelo et al., Biochem Biophys Res Commun 2003
(Fibrosarcoma) :
The butyrate effect was shown to be dependent on caspase activation, once
caspase inhibitors
restored phosphorylation of
ERK1/2 and CREB in 2C4 cells
Adayev et al., Biochim Biophys Acta 2003
:
However, both GFX and the PKCalpha and PKCbeta ( 1 ) inhibitor Gö6976 reversed the
ERK1/2 mediated inhibition of
caspase-3
Zhang et al., J Biol Chem 2003
:
Despite this, it completely suppresses PICD by sustaining
ERK activation and
inhibiting caspase 8 activation in phagocytosing neutrophils
Milani et al., J Neurochem 2003
(Neuroblastoma) :
Remarkably,
caspase dependent cleavage of NF-kappaB family members as well as of Akt and CREB proteins, but not of
ERK , became prominent at 24 h, a time point coincident with the peak of caspase dependent apoptosis
Guo et al., Blood 2003
:
In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase (
ERK ) 1/2,
activation of
caspase-1 , and secretion of interleukin-beta ( IL-1beta ) ... Specific inhibition of
ERK1/2 diminished Fas ligation
induced caspase-1 activation, IL-1beta secretion, and ensuing up-regulation of developmental markers, whereas treatment with neutralizing anti-IL-1beta antibody abrogated phenotypic and functional maturation, indicating that IL-1beta mediates Fas ligation induced DC maturation in an autocrine manner
Park et al., J Biol Chem 2003
:
Activation of
ERK1/2 by pretreatment with phorbol 12-myristate 13-acetate or forced expression of ERK1/2
attenuated phytosphingosine induced
caspase-8 activation
Lee et al., J Neurochem 2004
:
Interestingly, inhibition of
ERK dramatically increased mitochondrial malfunction, and
enhanced caspase activation, resulting in enhanced neuronal cell death
Zhang et al., Exp Cell Res 2004
:
Preincubation with hsp60 strongly induced phosphorylation of
ERK1/2 and
inhibited UV radiation mediated activation of
caspase 3
Liu et al., J Bone Miner Res 2004
:
The anti-apoptotic effect of calbindin-D28k involves inhibition of glucocorticoid induced
caspase 3 activation as well as
ERK activation
Marchetti et al., Cell Death Differ 2004
:
p53 can inhibit cell proliferation through
caspase mediated cleavage of
ERK2/MAPK ... Furthermore, caspase inhibitors or expression of a caspase-resistant ERK2 mutant interfere with ERK2 cleavage and restore proliferation in the presence of p53 activation, indicating that
caspase mediated
ERK2 degradation contributes to p53 induced growth arrest
Yacoub et al., Cancer Biol Ther 2004
(Brain Neoplasms...) :
Inhibition of
caspase 9 after combination treatment blunted neither JNK1/2/3 activation nor the enhanced expression of BAD and BAX, but did
block caspase 3 cleavage, reduced expression of BCL-XL and inhibition of
ERK1/2 activity
Schweyer et al., Br J Cancer 2004
(MAP Kinase Signaling System...) :
Functional assays using MEK inhibitors demonstrated that the phosphorylation of MEK and
ERK was
required for the activation of
caspase-3 as the executing caspase
Kaushal et al., American journal of physiology. Renal physiology 2004
:
Inhibition of
ERK1/2 phosphorylation but not P38 and JNK kinase
increased caspase-3 and -9 activation ; however, this activation was far less than induced by inhibition of Akt phosphorylation ... Thus the Akt mediated phosphorylation pathway,
ERK signaling, and the antiapoptotic Bcl-2 proteins distinctly
regulate caspase activation during oxidant injury to RTE
Schweyer et al., Int J Oncol 2004
(Neoplasms, Germ Cell and Embryonal...) :
Functional assays using chemical inhibitors demonstrated that the phosphorylation of
ERK was mediated by reactive oxygen species in an Raf-1 independent manner and
required the activation of
caspase-3
Tuo et al., Life Sci 2004
(MAP Kinase Signaling System) :
The opposing effects of onychin on phosphorylation levels of p38MAPK and
ERK1/2 , and its
caspase-3 inhibition might play a role in the beneficial effect of onychin on endothelial injury
Ríos-Muñoz et al., J Neurochem 2005
(MAP Kinase Signaling System...) :
In the present study we used western blotting and immunocytochemistry to investigate the effects of this FGF-2 treatment upon the activation of the extracellular signal regulated kinase (
ERK ) pathway, the amounts and distribution of Bcl-2 family proteins, and the
activation of
caspase-3
Shih et al., Food Chem Toxicol 2005
(Adenocarcinoma...) :
In addition, the malvidin treatment significantly increased the p38 kinase expression and inhibited the ERK activity, and the effects of malvidin on
caspase-3 activation were
blocked , respectively, by the
ERK and p38 inhibitors
Lüschen et al., Exp Cell Res 2005
:
This conclusion is based on the following observations : ( I ) Overexpression of FADD,
caspase-8 , or a c-FLIP protein containing the death effector domains only
leads to enhanced and prolonged
ERK activation after TNF treatment ... Interestingly, the enzymatic function of
caspase-8 is not
required for TNF induced
ERK activation
Weiderhold et al., Int J Cancer 2006
(Mammary Neoplasms, Animal) :
Bcl-2 phosphorylation and
activation of
ERK and JNK and
caspase 3-dependent cleavage of PARP were observed in MDA-MB-435 cells treated with CB694
El Btaouri et al., Biochem Biophys Res Commun 2006
(MAP Kinase Signaling System) :
The permeable exogenous C ( 2 ) -ceramide reproduces IL-1beta effects on: (i) inhibition of adenylyl cyclase activity, ( ii ) down-regulation of
ERK1/2 phosphorylation, ( iii )
activation of
caspase-3 , and ( iv ) apoptosis in pig thyroid cells
Panner et al., Cell cycle (Georgetown, Tex.) 2006
:
While TRAIL sensitivity in tumors has been linked to c-myc- and
MEK/Erk induced enhancement of
caspase activation, our recent study identified a third input controlling TRAIL sensitivity, namely the Akt-mTOR pathway
Kim et al., Environ Toxicol Chem 2005
(Necrosis) :
Inhibition of
ERK phosphorylation by PD98059 strongly attenuated cadmium induced necrotic cell death, but did not
prevent caspase-3 activation and DNA fragmentation
Cagnol et al., Apoptosis 2006
:
Prolonged activation of
ERK1,2 induces FADD independent
caspase 8 activation and cell death ... Accordingly, prolonged
ERK stimulation
activated caspase 8 and strongly potentiated Fas signaling ... These findings reveal that prolonged
ERK/MAPK stimulation
results in
caspase 8 activation and cell death
Sumizawa et al., Arch Toxicol 2007
:
Thus, although mechanisms other than caspase dependent apoptosis may be involved, apoptotic process seems to take place in the genesis of toxicity of acrylamide in SH-SY5Y cells through
ERK pathway and
activation of
caspase-3
Raymond et al., Endocrinology 2006
(Leiomyoma...) :
A pharmacological approach showed that the effect of ET-1 on
caspase-3/7 activation in ELT3 cells was not
dependent on phosphatidylinositol 3-kinase,
ERK1/2 , or phospholipase D activities
Xu et al., Atherosclerosis 2007
:
Inhibitors of the Akt,
ERK1/2 , Src kinase and transfection with a dominant negative Akt cDNA
blocked the inhibitory effect of cyanidin on cleaved
caspase-3
Huang et al., Am J Physiol Cell Physiol 2007
:
Moreover, inhibition of
ERK phosphorylation
potentiated serum withdrawal induced
caspase-3 activity
Ou et al., Eur J Pharmacol 2007
(Carcinoma, Renal Cell...) :
Selective inhibitors of
ERK , p38 MAPK, and JNK suppressed the induction of GRP78, CHOP, and PPAR-beta, attenuated indomethacin induced cytotoxicity and
reduced increased
caspase activity
Zhou et al., Cell Prolif 2007
(MAP Kinase Signaling System) :
The suppression of
MEK1/ERK1/2 activation
inhibited UV-induced expression of c-Fos and JunD and increased
caspase 3 activity and cell death
Bhoopathi et al., J Biol Chem 2008
(MAP Kinase Signaling System...) :
ERK inhibition, using a kinase-dead mutant for ERK, ameliorated NF-kappaB activation and
caspase mediated apoptosis in Ad-MMP-9 infected cells
Aprigliano et al., Liver Int 2008
(Disease Models, Animal) :
Atorvastatin induces apoptosis in activated HSCs acting through an
ERK dependent cleavage of Bid and a highly increased protease activity of
caspase-9 and -3
Zhou et al., Toxicol Appl Pharmacol 2008
:
Knockdown of JWA attenuated arsenic trioxide induced apoptosis, and was accompanied by significantly reduced activity of
caspase-9 , enhanced Bad phosphorylation and
inhibited MEK1/2,
ERK1/2 and JNK phosphorylations
Kong et al., Purinergic Signal 2005
:
BzATP also induced the activation of C-jun N-terminal kinase 1 ( JNK1 ) and extracellular signal regulated kinases ( ERK1/2 ) in rPCNs, and pharmacological inhibition of either JNK1 or
ERK1/2 significantly
reduced caspase activation by BzATP
Monick et al., J Immunol 2008
:
ERK inhibition
led to cytosolic release of mitochondrial proteins and
caspase activation
Zhang et al., Toxicology 2008
:
Inhibition of
ERK1/2 activation sensitized hepatocytes to death and
increased activity of
caspase-9 and 3 in response to toosendanin
Cheng et al., Int J Cancer 2008
(Lung Neoplasms...) :
Moreover,
caspase-3 induced
ERK activation ... In summary,
caspase-3 induces
ERK activation through a ceramide-dependant, protease activity independent mechanism, which represents a novel role of caspase-3 in tumor metastasis
Kim et al., Biol Pharm Bull 2009
(Hearing Disorders) :
HGCYT inhibited the cell death, reactive oxygen species generation ( ROS ),
activation of
caspase-9 , and extracellular signal related kinase (
ERK ) induced by Cd ( 2+ )
Hasegawa et al., J Immunol 2009
:
ASC mediated AP-1 activation was inhibited by chemical or protein inhibitors for caspase-8, caspase-8 targeting small interfering RNA, and p38 and JNK inhibitors, but not by a caspase-1 inhibitor,
caspase-9 or Fas associated death domain protein ( FADD ) dominant negative mutants, FADD- or RICK targeting small interfering RNAs, or a MEK inhibitor, indicating that the ASC induced AP-1 activation is mediated by caspase-8, p38, and JNK, but does not
require caspase-1, caspase-9, FADD, RICK, or
ERK
Yang et al., BMC biology 2009
(Brain Ischemia...) :
Since
ERK and cytochrome c are differentially
involved in
caspase signaling of oxidative injury that significantly contributes to neuronal damage in ischemia/reperfusion, we considered if DOR activation protects the ischemic brain by attenuating oxidative injury
Gatson et al., Journal of neuroinflammation 2009
(Burns...) :
In addition, we determined that in the estrogen treated rats there was an increase in the levels of
phospho-ERK ( p < 0.01 ) and Akt ( p < 0.05 ) at the 24 hour time-point, and that 17 beta-estradiol
blocked the activation of
caspase-3 ( p < 0.01 ) and subsequent cleavage of PARP ( p < 0.05 )
Kim et al., J Toxicol Environ Health 2009
:
Fifty micromolar HQ markedly increased phosphorylation of
ERK and
activation of
caspase-9/-3 , followed by PARP cleavage
Lennartsson et al., Cell Signal 2010
:
However, reduction of the expression of
Erk5 by siRNA
resulted in only a transient Akt phosphorylation, and an inability of PDGF-BB to suppress
caspase 3 activation and inhibit apoptotic nuclear morphological changes such as condensed or fragmented chromatin under serum-free conditions
Inamura et al., J Anesth 2010
(Reperfusion Injury) :
This
caspase activation is
mediated by phosphorylation of Akt and
ERK
Härtel et al., Am J Physiol Cell Physiol 2010
:
This endogenous process involves
MEK/ERK mediated inhibition of the pro-apoptotic molecule Bad and
caspase 3
Zeng et al., J Ethnopharmacol 2010
:
In addition, MWG extract attenuated activation of
caspase-3 and poly ADP-ribose polymerase ( PARP ) and
inhibited the phosphorylation of
ERK , c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs
Snyder et al., AIDS 2010
(AIDS-Associated Nephropathy...) :
Since sustained ERK activation can activate caspase-8 in some cell types, we studied the
role of
ERK in Vpr induced
caspase-8 activation
Lee et al., Endocrinology 2010
(Spinal Cord Injuries) :
Ghrelin significantly inhibited apoptotic cell death of neurons and oligodendrocytes, release of mitochondrial cytochrome c, and activation of
caspase-3 after moderate contusion SCI. Ghrelin also significantly
increased the level of phosphorylated
ERK but decreased the level of phosphorylated p38MAPK
Scherbik et al., J Virol 2010
(MAP Kinase Signaling System...) :
Reduction of Ca ( 2+ ) influx at early times of infection by various treatments decreased the viral yield and delayed both the early transient
caspase 3 cleavage and the
activation of FAK, Akt, and
ERK signaling
Lu et al., Sci China Life Sci 2010
:
Full inhibition of
caspase-3 activity reduced Mst1 activation and partially inhibited H2B phosphorylation ( Ser14 ), but
ERK1/2 , JNK1/2 and p38 activities were not
affected
Lee et al., Mol Biol Cell 2010
:
HGF also blocked Ang II-induced
caspase-3 activation and lactate dehydrogenase release in tissue explants in an
ERK dependent manner
Yang et al., Biochem Pharmacol 2011
(Liver Neoplasms) :
In fenretinide sensitive Huh7 cells, activation of
ERK1/2 by epidermal growth factor (EGF)
prevented fenretinide induced cell death and
caspase 3/7 induction
Tsuda et al., BMC neuroscience 2011
(Sciatic Neuropathy) :
In the present study, axonal outgrowth,
activation of
ERK1/2 by phosphorylation ( p-ERK 1/2 ) and immunoreactivity of cleaved
caspase 3 were examined after immediate, delayed, or no repair of transected rat sciatic nerves
Wang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011
:
Reduction of MC3T3 cell surface cholesterol dramatically inhibited TNFR1 mediated AKT phosphorylation, while did not affect the degradation of I?Ba,
activation of
ERK or p38, and processing of
caspase-3 induced by TNF-a
Jabbour et al., Transplantation 2011
(Myocardial Reperfusion Injury) :
Functional improvements were accompanied by increased phosphorylation of Akt,
ERK1/2 , STAT3, and GSK-3ß and
reduced cleaved
caspase-3 ( P < 0.01 )
Tomiyama et al., Cell death & disease 2010
(Glioma) :
MEK-ERK dependent multiple
caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation induced glioma cell death
Xiang et al., Cell Biochem Funct 2011
:
The inhibitory effect of ghrelin on
caspase-3 activity was
attenuated by inhibitors of
ERK1/2 ( PD98059 ), PI3K/Akt ( LY294002 ) and growth hormone secretagogue receptor ( GHSR ) -1a ( D-Lys ( 3 ) -growth hormone releasing peptide-6 )
Jantas et al., Neurotoxicology 2011
:
The obtained data provided evidence for neuroprotective potency of
MAPK/ERK1/2 and calpain, but not
caspase-3 inhibition against the neurotoxic effects of LC in primary cortical neurons and give rationale for using these inhibitors in the treatment of neurodegenerative diseases connected with proteasome dysfunction
Brama et al., J Endocrinol Invest 2012
(MAP Kinase Signaling System...) :
In conclusion, at least 2 pathways appear activated by cadmium in osteoblasts : a direct induction of caspase-8 followed by activation of
caspase-3 and an indirect
induction by phosphorylation of
ERK1/2 , p38, and JNK MAPK triggering activation of caspase-8 and -3
Liu et al., Int J Biochem Cell Biol 2011
(Breast Neoplasms) :
Taken together, our data indicate that
Akt/ERK mediated caspase-8 activation and Fas/FasL mediated
caspase-8 activation mostly elucidate doxorubicin induced death in MCF-7 cells and MCF-7/Dox cells, respectively
Karmarkar et al., PloS one 2011
(MAP Kinase Signaling System) :
Facilitation of
ERK activation and
inhibition of
caspase activation promotes resistance to Glu excitotoxicity in SCN2.2 cells
Beharier et al., J Mol Med (Berl) 2012
(MAP Kinase Signaling System...) :
Overexpression of ZnT-1 markedly reduced LDH release and caspase activation following I/R. Knockdown of endogenous ZnT-1 augmented the I/R induced release of LDH and increased
caspase activation following I/R.
Phospho-ERK levels were significantly increased following I/R in cells overexpressing ZnT-1, while knockdown of ZnT-1 reduced phospho-ERK levels
Bodai et al., Bioessays 2012
(Huntington Disease...) :
In response to mutant Htt,
ERK is activated and directs a protective transcriptional response and
inhibits caspase activation
Zhai et al., Pharmacol Rep 2011
:
Moreover, CSTMP showed stronger effects on the inhibition of apoptosis,
caspase-3 expression, and the
activation of phosphorylated
ERK1/2 compared to RES
Yuan et al., Biochem Biophys Res Commun 2012
(MAP Kinase Signaling System) :
The activation of
ERK increased XIAP expression and
led to decreased
caspase activation
Han et al., Cell Signal 2012
:
In addition, down-regulation of
ERK resulted in activation of
caspase 3 and caspase 9
Park et al., Int J Oncol 2013
:
ROS and
ERK1/2 mediated
caspase-9 activation increases XAF1 expression in dexamethasone induced apoptosis of EBV transformed B cells ... These results demonstrated that Dex mediated activation of caspase-9 via ROS generation and
ERK1/2 pathway activation
resulted in the activation of
caspase-8 and the increment of XAF1, thereby induced apoptosis of EBV transformed B cells