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SLC22A3 — SMAD9

Text-mined interactions from Literome

Rhyu et al., J Am Soc Nephrol 2005 (Fibrosis...) : Phosphorylation of Smad proteins and/or mitogen activated protein kinases ( MAPK ) is required for TGF-beta1 induced EMT
Desgrosellier et al., Dev Biol 2005 : Smad6, an inhibitor of Smad signaling downstream of ALK2, but not ALK5, inhibited EMT in AV cushion endocardial cells
Liu et al., Perit Dial Int 2008 (Fibrosis...) : Phosphorylation of Smad proteins is required for TGFbeta1 induced EMT
Miyazono et al., Proc Jpn Acad Ser B Phys Biol Sci 2009 (Disease Progression...) : Multiple transcription factors, including deltaEF1/ZEB1, SIP1/ZEB2, and Snail/SNAI1, are induced by TGF-beta-Smad signaling and play critical roles in TGF-beta induced EMT ... In addition, both non-Smad signaling activated by TGF-beta and cross-talk with other signaling pathways play important roles in induction of EMT
Zhou et al., J Am Soc Nephrol 2010 : Because Smad proteins transduce TGF-beta signaling from the cytosol to the nucleus and HSP72 assists in protein folding and facilitates nuclear translocation, we investigated whether HSP72 inhibits TGF-beta induced EMT by modulating Smad expression, activation, and nuclear translocation
Townsend et al., Cells Tissues Organs 2011 : Targeting of Smad4, the common mediator Smad, demonstrated that Smad signaling is required for EMT in the AVC and TGFßR3 dependent EMT stimulated by TGFß2 or BMP-2
Park et al., Cancer Sci 2011 (Cell Transformation, Neoplastic...) : The novel ALK5 inhibitor, EW-7203, efficiently inhibited TGF-ß1 induced Smad signalling, EMT and breast tumor metastasis to the lung in vivo, demonstrating that EW-7203 has therapeutic potential for breast cancer metastasis to the lung
Ai et al., J Natl Cancer Inst 2011 (Adenocarcinoma...) : Furthermore, high expression of pIgR was sufficient to induce EMT through activation of Smad signaling