Gene interactions and pathways from curated databases and text-mining

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AKT1S1 — SREBF1

Text-mined interactions from Literome

Wong et al., Curr Opin Pharmacol 2010 (Metabolic Diseases) : SREBP-1c can be induced by mTORC1 , bifurcating lipogenesis from AKT activated gluconeogenesis
Yecies et al., Cell Metab 2011 : Therefore, mTORC1 activation is not sufficient to stimulate hepatic SREBP1c in the absence of Akt signaling, revealing the existence of an additional downstream pathway also required for this induction