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CDKN1A — KLF4

Text-mined interactions from Literome

Zhang et al., J Biol Chem 2000 : The gut enriched Kruppel-like factor ( Kruppel-like factor 4 ) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter
Wu et al., Oncogene 2004 : In addition, KLF2 upregulates p21WAF1/CIP1 expression
Zhu et al., Brain Res 2009 : KLF4 overexpression also increased both protein and mRNA levels of the cell cycle protein cyclin D1, but reduced p21 ( Waf1/Cip1 ) protein levels
Traka et al., Nutr Cancer 2009 : Involvement of KLF4 in sulforaphane- and iberin mediated induction of p21 ( waf1/cip1 ) ... Here we evaluate the role of the transcription factor Kruppel-like factor 4 (KLF4) in mediating the induction of p21 ( waf1/cip1 ) and cellular differentiation by SF and iberin ( IB ; 3-methylsulphinyl propyl isothiocyanate ), also derived from broccoli ... Additional support for the SF-mediated induction of p21 ( waf1/cip1 ) by KLF4 was obtained from analyses of gastric tissue of Apc ( Min/+ ) mice following acute intervention with SF but not from the analyses of other tissue of the intestinal tract ... These results suggest that induction of p21 ( waf1/cip1 ) by SF or IB may be partly mediated by KLF4 in some colon cancer cells and tissues
Zhou et al., Cancer Biol Ther 2010 (Lung Neoplasms...) : This effect was independent of KLF4 mediated p21 up-regulation because ectopic expression of p21 had minimal effect on cell invasion
Wei et al., Gastroenterology 2010 (Carcinoma, Pancreatic Ductal...) : Transgenic expression of KLF4a reduced expression of p27 ( Kip1 ) and p21 ( Cip1 ), promoting cell cycle progression and in vivo tumor formation by pancreatic cancer cells
Song et al., Biochem Biophys Res Commun 2012 (Papilloma) : Furthermore, KLF10 dose-dependently activated p21 ( WAF1/CIP1 ) transcription, which was independent of p53 and Sp1 binding sites in p21 ( WAF1/CIP1 ) promoter