Gene interactions and pathways from curated databases and text-mining

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NPY6R — SYK

Text-mined interactions from Literome

Polanowska-Grabowska et al., Arterioscler Thromb Vasc Biol 2003 : PP2 , although having no effect on RGD peptide binding to CRP, completely blocked aggregation and tyrosine phosphorylation of Syk and phospholipase Cgamma2 ( PLCgamma2 ) ... Although PP2 prevented activation of Syk and PLCgamma2 in collagen-adherent platelets, tyrosine phosphorylation of several unidentified protein bands persisted, as did autophosphorylation of pp125FAK
Lee et al., Arch Pharm Res 2007 : PDGF-BB ( 10 ng/mL ) induced the migration and proliferation of RASMCs, which were significantly inhibited by PP2 ( 10 microM ) and piceatannol ( 30 microM ), inhibitors of Src and Syk , respectively
Won et al., J Pharmacol Sci 2008 : The phosphorylation of cofilin in RASMCs was decreased by PDGF-BB treatment at 10 min, but recovered to the level of the quiescent state at 60 min. PDGF-BB induced dephosphorylation of cofilin was inhibited by pretreatment with piceatannol ( a spleen tyrosine kinase [ Syk ] inhibitor ), PP2 ( a Src inhibitor ), or SP600125 ( a c-Jun N-terminal kinase [ JNK ] inhibitor ), but not by PD98059, an inhibitor of extracellular signal regulated kinase 1/2