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IGF1 — MMP14

Text-mined interactions from Literome

Zhang et al., Oncogene 2003 (Carcinoma, Lewis Lung...) : Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling ... Here, we investigated the role of IGF-IR in the regulation of MT1-MMP
Stearns et al., Clin Cancer Res 2003 (Prostatic Neoplasms) : The data show that IL-10 blocks IGF-I activation of MMP-2 and MT1-MMP mRNA expression and protein synthesis in primary prostate cell strains
Stawowy et al., Biochem Biophys Res Commun 2004 : Both, IGF-1 and PDGF-BB, induced MT1-MMP expression, but only IGF-1 mediated MT1-MMP induction was inhibited by dec-CMK ... Both, IGF-1 and PDGF-BB, induced MT1-MMP expression, but only IGF-1 mediated MT1-MMP induction was inhibited by dec-CMK ... In conclusion, this study demonstrates that targeting furin-like PCs and thus inhibiting IGF-1R activation is a novel target to inhibit IGF-1 mediated signaling and cell functions, such as IGF-1 induced MT1-MMP/MMP-2 in VSMCs
Jenniskens et al., Osteoarthritis Cartilage 2006 : TGFbeta2 and IGF1 had no effect on MMP activity
Hiden et al., J Clin Endocrinol Metab 2012 (Diabetes, Gestational...) : Pathophysiological levels of insulin and IGF-II, but not IGF-I and glucose, stimulated MT1-MMP expression in fpEC by phosphatidylinositol 3-kinase signals relayed through the insulin, but not IGF-I, receptor