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PTGS2 — VEGFA
Text-mined interactions from Literome
Hernández et al., J Exp Med 2001
:
Here we show that CsA inhibits migration of primary endothelial cells and angiogenesis induced by vascular endothelial growth factor ( VEGF ) ; this effect appears to be mediated through the inhibition of
cyclooxygenase (Cox)-2 , the transcription of which is
activated by
VEGF in primary endothelial cells ... Consistent with this, we show that the
induction of
Cox-2 gene expression by
VEGF requires NFAT activation
Murono et al., Proc Natl Acad Sci U S A 2001
(Nasopharyngeal Neoplasms...) :
Induction of
cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is
involved in
vascular endothelial growth factor production in nasopharyngeal carcinoma cells
Ishiko et al., Oncol Rep 2001
(Carcinoma in Situ...) :
In conclusion, the expression of
COX-2 in ACC may
induce the expression of
VEGF , increase angiogenesis and enhance tumor growth and invasion
Akarasereenont et al., Mediators Inflamm 2002
:
Thus, the
induction of
COX-2 by
VEGF in endothelial cells was mediated through protein tyrosine kinase, and the uses of specific COX-2 inhibitors in these conditions, in which VEGF was involved, might have a role
Tamura et al., J Clin Endocrinol Metab 2002
:
Pretreatment of HMEC-1 with a selective COX-2 inhibitor, NS-398, abolished VEGF induced PGE ( 2 ) synthesis, suggesting specific
up-regulation of
COX-2 activity by
VEGF in HMEC-1 ... Transient transfection assays using deletion mutants of the human COX-2 promoter fused to the luciferase reporter gene indicated critical requirement of a regulatory region spanning -828/-123 bp for
VEGF induction of
COX-2 promoter activity in HMEC-1
Yoshizaki et al., Histol Histopathol 2002
(Carcinoma...) :
LMP-1 also
induces vascular endothelial growth factor through
cyclooxygenase-2 activation and interleukin-8 through NF-kappaB activation
Ma et al., Proc Natl Acad Sci U S A 2002
(Neovascularization, Pathologic...) :
Therefore, we compared the
effects of a nonselective COX inhibitor ( flurbiprofen ), a nitric oxide releasing COX inhibitor ( HCT-1026 ), and a selective
COX-2 inhibitor ( celecoxib ) on gastric ulcer healing, angiogenesis, and platelet/serum levels of
vascular endothelial growth factor ( VEGF ) and endostatin
Liu et al., J Biol Chem 2002
(Anoxia...) :
We reported previously that
COX-2 inhibition prevents hypoxic up-regulation of VEGF in human prostate cancer cells and that prostaglandin E ( 2 ) ( PGE ( 2 ) )
restores hypoxic effects on
VEGF
Eibl et al., Biochem Biophys Res Commun 2003
(Pancreatic Neoplasms) :
PGE ( 2 ) is generated by specific
COX-2 activity and
increases VEGF production in COX-2 expressing human pancreatic cancer cells
Wu et al., Am J Physiol Heart Circ Physiol 2003
(Anoxia...) :
COX-2 was significantly
induced by
VEGF ( 4.86 +/- 1.03-fold ) and IL-1beta ( 3.93 +/- 0.89-fold ) and slightly increased by TNF-alpha but not by FGF2, IGF-1, or PDGFs. Analysis of proteins secreted in HMCM showed increased levels of VEGF but not IL-1 beta or TNF-alpha ...
VEGF induced endothelial cell
COX-2 expression by both increasing COX-2 transcription and prolonging the COX-2 mRNA half-life ... Both a selective PKC-alpha and -beta inhibitor and an inducible nitric oxide synthase (NOS) inhibitor decreased the
induction of
COX-2 by HMCM and
VEGF
Leung et al., Int J Oncol 2003
(Carcinoma...) :
Cyclooxygenase-2 upregulates
vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma
Yoshida et al., Lab Invest 2003
(Carcinoma, Lewis Lung...) :
In this model,
VEGF expression was
down-regulated by selective
COX-2 inhibition with NS-398
Wang et al., Biochem Biophys Res Commun 2004
:
Thus, vHL/HIF-1alpha has a regulatory role in
COX-2 mediated
VEGF production in hypoxic stellate cells in injured liver
Spinella et al., Clin Cancer Res 2004
(MAP Kinase Signaling System...) :
COX-2 inhibitors and, in part, COX-1 inhibitor
blocked ET-1 induced PGE ( 2 ) and
vascular endothelial growth factor release, indicating that both enzymes participate in PGE ( 2 ) production to a different extent
Kyzas et al., Mod Pathol 2005
(Carcinoma, Squamous Cell...) :
Our results suggest that a lymphangiogenic pathway, in which
COX-2 overexpression
stimulates vascular endothelial growth factor-C upregulation, probably exists in head and neck squamous cell carcinoma
Shin et al., Carcinogenesis 2004
(Adenocarcinoma...) :
Furthermore, the stimulatory action of nicotine on cancer cell growth and angiogenic factor
VEGF production was
suppressed by inhibitors of MEK ( U0126 ) and
COX-2 ( SC-236 )
Calviello et al., Carcinogenesis 2004
(Colorectal Neoplasms) :
Constitutive
VEGF expression was
augmented in cultured HT-29 cells by serum starvation and the effects of eicosapentaenoic ( EPA ) or docosahexaenoic acid ( DHA ) on VEGF,
COX-2 , phosphorylated extracellular signal regulated kinase ( ERK ) -1 and -2 and hypoxia-inducible-factor 1-alpha ( HIF-1alpha ) expression and PGE ( 2 ) levels were assessed
Youn et al., Immunol Lett 2005
(Arthritis, Rheumatoid...) :
New
cyclooxygenase-2 inhibitor DFU
regulates vascular endothelial growth factor expression in rheumatoid synoviocytes
Diamond et al., Fertil Steril 2005
(Tissue Adhesions) :
Stimulation of aerobic metabolism by DCA or inhibition of
COX-2 by NS-398
reduces VEGF expression
Eibl et al., Cancer Res 2005
(Neovascularization, Pathologic...) :
The aim of the present study was to evaluate the
effect of selective
COX-2 inhibitors on
vascular endothelial growth factor ( VEGF ) production in vitro and angiogenesis and growth of pancreatic cancer in vivo, focusing on putative differences between COX-2 negative and COX-2 positive tumors ... Selective
COX-2 inhibitors
had a concentration dependent effect on
VEGF production in vitro
Huang et al., J Biomed Sci 2005
(Neovascularization, Pathologic...) :
Cyclooxygenase-2 increases hypoxia-inducible factor-1 and
vascular endothelial growth factor to promote angiogenesis in gastric carcinoma ... These in vitro angiogenic effects on HUVECs were reduced either by blocking
VEGF or NS-398, a
COX-2 inhibitor
Wu et al., World J Gastroenterol 2005
(Helicobacter Infections...) :
These effects appear to be mediated through a NF-kappaB and COX-2 mediated pathway, as
COX-2 or NF-kappaB inhibitor significantly
attenuate the invasiveness of gastric cancer cells and the expressions of MMP-9 and
VEGF protein
Kimba et al., Oncol Res 2005
(Anoxia...) :
Mutant IkappaBalpha suppresses hypoxia
induced VEGF expression through downregulation of HIF-1alpha and
COX-2 in human glioma cells
Cianchi et al., Clin Cancer Res 2005
(Colorectal Neoplasms) :
The
role of
cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and
vascular endothelial growth factor production in colorectal cancer
Imada et al., Int J Mol Med 2006
(Breast Neoplasms...) :
COX-2 induces
vascular endothelial growth factor ( VEGF ) and basic fibroblast growth factor (bFGF) and is thus involved in neovascularization
Soma et al., Int J Cancer 2006
(Disease Progression...) :
In vitro, CDCA induced the production of PGE2 and
VEGF in dose- and time dependent manners, and these effects were
attenuated by a selective
COX-2 inhibitor, mitogen activated protein kinases inhibitor, or epidermal growth factor receptor inhibitor ... CDCA induced
COX-2 in the cell lysate
increased the secretion of
VEGF into the culture medium
Tamura et al., Vascul Pharmacol 2006
:
VEGF induced cyclooxygenase
(COX) -2 mRNA expression in HUVECs and increased the PGE2 concentration in the medium
Murphy et al., Circ Res 2006
(Ischemia) :
The function of sokotrasterol sulfate was dependent on
cyclooxygenase-2 activity and
vascular endothelial growth factor induction , as inhibition of either cyclooxygenase-2 or vascular endothelial growth factor blocked angiogenesis
Ueno et al., Biomed Pharmacother 2006
(Breast Neoplasms) :
Further studies are necessary to elucidate how
COX-2 inhibitors
regulate production of
VEGF in different cells and different tissues in cancer patients
Li et al., Int J Gynecol Cancer 2006
(Endometrial Neoplasms...) :
The present findings suggest that overexpression of
COX-2 may
induce the expression of
VEGF , increase angiogenesis, and enhance tumor growth
Güven et al., J Endod 2007
:
Recent data from the medical literature indicates that
cyclooxygenase-2 (COX-2) plays a key role in the production of
vascular endothelial growth factor ( VEGF ), a glycoprotein that has the ability to increase the permeability of blood vessels and to induce angiogenesis
Spinella et al., Cancer Res 2007
(Melanoma...) :
Moreover,
COX-1/COX-2 inhibitors
block ET-induced PGE ( 2 ) and
VEGF secretion, matrix metalloproteinase ( MMP ) activation, and cell invasion, indicating that both enzymes function as downstream mediators of ET-induced invasive properties
Boosani et al., Blood 2007
(Neoplasms...) :
We show that binding of alpha3 ( IV ) NC1 to alpha3beta1 integrin leads to inhibition of
COX-2 mediated pro-angiogenic factors,
vascular endothelial growth factor , and basic fibroblast growth factor by regulating IkappaBalpha/NFkappaB axis, and is independent of alphaVbeta3 integrin
Gollogly et al., J Surg Res 2007
:
In endothelial cells, binding of
vascular endothelial growth factor ( VEGF ) to VEGF receptor 2
leads to the activation of the serine/threonine phosphatase calcineurin, dephosphorylation of the nuclear factor of activated T-cells ( NF-AT ) transcription factors, translocation of NF-AT to the nucleus, and expression of angiogenesis related genes such as
Cox-2
Oshima et al., Exp Anim 2007
:
Moreover, expression of
vascular endothelial growth factor ( VEGF ) is also induced in the heart in a
COX-2 dependent manner
Lei et al., Zhonghua Yi Xue Za Zhi 2007
(Neoplasms, Experimental...) :
COX-2 can
stimulate VEGF and enhance the proliferation of endothelial cells by upregulating Id1, and blocking this pathway may be helpful to the tumor therapeutics, so COX-2 and Id1 can be exploited as therapeutic targets of gastric cancer
Zhu et al., BMC cancer 2008
(Carcinoma, Non-Small-Cell Lung...) :
Effects of
COX-2 inhibition on expression of
vascular endothelial growth factor and interleukin-8 in lung cancer cells ... We speculated that inhibition of
COX-2 activity might
reduce expression of the pro-angiogenic factors
vascular endothelial growth factor ( VEGF ) and interleukin-8 (IL-8) in lung cancer cells ... However,
VEGF production is, at least partly,
COX-2 dependent in NSCLC cells expressing COX-2
Brant et al., Toxicological sciences : an official journal of the Society of Toxicology 2009
:
Consistent with our previous findings that Ni and MALP-2 stimulates the induction of CXCL8 via a COX-2 mediated pathway, CXCL1, CXCL5, and
VEGF release were also
regulated by
COX-2
Tjiu et al., J Invest Dermatol 2009
(Carcinoma, Basal Cell...) :
Macrophages also induced
COX-2 dependent secretion of basic fibroblast growth factor and
vascular endothelial growth factor-A , and increased angiogenesis in BCC cells
Valcárcel et al., Journal of translational medicine 2008
(Colorectal Neoplasms...) :
More importantly, spheroid derived CT26 cells increased lymphocyte function associated antigen ( LFA ) -1-expressing cell fraction by 3-fold ; and soluble intercellular adhesion molecule (ICAM)-1, given to spheroid cultured CT26 cells, further increased
VEGF secretion by 90 %, via cyclooxygenase
(COX)-2 dependent mechanism
Hu et al., Proc Natl Acad Sci U S A 2009
(Breast Neoplasms...) :
Up-regulation of
COX-2 in DCIS xenografts
resulted in increased
VEGF and MMP14 expression, which may contribute to the larger weight and invasive histology of COX-2 expressing tumors
Liu et al., Anat Rec (Hoboken) 2009
(Adenocarcinoma...) :
Here, the
effects of
COX-2 inhibitor on
vascular endothelial growth factor-C ( VEGF-C ) expression, lymphangiogenesis and lymph node metastasis were investigated
Doyle et al., Domest Anim Endocrinol 2010
:
The
PTGS2 response to 1 ng/mL
VEGF was similar to that induced by treatment with luteinizing hormone ( LH )
Chien et al., Carcinogenesis 2009
(MAP Kinase Signaling System...) :
However,
VEGF-C induced
COX-2 upregulation was effectively abolished by overexpression of dominant negative c-Jun N-terminal kinase (JNK) or treatment with the JNK inhibitor, SP 600125
Valamanesh et al., Molecular vision 2009
:
Experiments performed on primary RPE cells showed that TA downregulates the basal expression of
COX-2 and VEGF and
inhibits the outer segments ( OS ) -dependent COX-2 induction but not the OS-dependent
VEGF induction
Scoditti et al., Cardiovasc Res 2010
:
As both protein kinase C (PKC)alpha and beta are involved in
VEGF induced
COX-2 expression and CREB activation, we investigated which isoform ( s ) of PKC was affected by RSG ...
VEGF induces CREB mediated
COX-2 expression through a PKCalpha dependent pathway in human endothelium ... The anti-angiogenic effect of PPARgamma agonists is due, at least in part, to an interference with the
VEGF stimulated PKCalpha mediated activation of CREB and the related expression of
COX-2
Toomey et al., Pancreas 2010
(Neovascularization, Pathologic...) :
This study delineated the
role of
COX-2 and nonsteroidal anti-inflammatory drugs in angiogenesis and
VEGF regulation ...
Cyclooxygenase 2 does not
regulate VEGF in pancreatic cancer, and celecoxib upregulates VEGF in pancreatic cancer
Park et al., Head Neck 2010
(Carcinoma, Squamous Cell...) :
The majority of the anticancer effects of COX-2-inhibitors in HNSCC cells seem to result from COX-2 independent action, suggesting that COX-1 and
COX-2 may
contribute to
VEGF synthesis in cancer cells through a prostaglandin dependent mechanism
Yao et al., J Exp Clin Cancer Res 2011
(Neoplasms, Experimental...) :
The results of RT-PCR and western blot showed that down-regulation of
COX-2 might
inhibit VEGF , Flt-1, Flk-1/KDR, angiopoietin-1, tie-2, MMP2 and OPN
Kim et al., Korean journal of urology 2011
:
Chronic inflammation in BPH causes an overexpression of
COX-2 , which
induces the increased expression of Bcl-2 and
VEGF
Zhao et al., Mol Cell Biochem 2012
(MAP Kinase Signaling System) :
VEGF production in PDGF stimulated HSCs is
dependent on the overexpression of
COX-2 protein via the phospho-p42/44 MAP kinase activation, based on PD98059 inhibition
Valcárcel et al., Journal of translational medicine 2011
(Bone Marrow Neoplasms...) :
Recombinant TNFa induced B16M production of
VEGF via
COX-2 dependent mechanism ... We demonstrate the contribution of
VEGF induced tumor
COX-2 to the regulation of adhesion- and proliferation stimulating effects of TNFa, from endotoxin activated bone marrow stromal cells, on VLA-4 expressing melanoma cells
Cintra et al., Clinics (Sao Paulo) 2011
(Bone Neoplasms...) :
Angiogenesis can be quantified by measuring the expression of
vascular endothelial growth factor and CD34, and
cyclooxygenase-2 can
induce angiogenesis by stimulating the production of proangiogenic factors
Ji et al., International journal of medical sciences 2012
(Neovascularization, Pathologic...) :
Our
results suggest that expression of
COX-2 and
VEGF may promote angiogenesis of thyroid carcinoma, its infiltration, and metastasis
Garufi et al., PloS one 2012
:
THESE FINDINGS SHOW THAT : 1 ) HIPK2 knockdown induced COX-2 upregulation, mostly depending on HIF-1 activity ; 2 ) zinc treatment downregulated HIF-1 induced
COX-2 and
inhibited PGE ( 2 )
/VEGF production ; and 3 ) zinc treatment of HIPK2 depleted cells restored DCs maturation
Salimi et al., J Environ Pathol Toxicol Oncol 2012
(Carcinoma, Squamous Cell...) :
This study was designed to evaluate the action of nicotine in the oral cancer cell and to further examine whether
COX-2 is
responsible for expression of tumor associated angiogenic
vascular endothelial growth factor ( VEGF ) in vitro
Voloshin et al., Anesteziol Reanimatol 2013
(Pain, Postoperative) :
It is assumed that the
COX-2 inhibitors may
inhibit vascular endothelial growth factor of the tumor and so inhibit angiogenesis of solitary tumors and metastases, without affecting the normal endothelium