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EGF — SNAI2

Text-mined interactions from Literome

Kusewitt et al., J Invest Dermatol 2009 : Epidermal growth factor (EGF) induces Slug expression and the response to EGFR activation is more robust than to other receptor tyrosine kinase ligands
Yang et al., BMC cancer 2010 (Brain Neoplasms...) : SNAI2 mRNA expression correlated with histologic grade and invasive phenotype in primary human glioma specimens, and was induced by EGF receptor activation in human glioblastoma cells
Cheng et al., Mol Endocrinol 2010 (Ovarian Neoplasms) : PEG-catalase and the p38 MAPK inhibitor SB203580 abolished EGF induced Snail, but not Slug , expression and E-cadherin down-regulation
Xu et al., Biochem Biophys Res Commun 2010 (Ovarian Neoplasms) : Here, we show that transforming growth factor ß ( TGFß ) and epidermal growth factor (EGF) synergistically induce the expression of Slug and Snail at both mRNA and protein levels in an EOC cell line OVCA429 cells ... Using specific chemical inhibitors, we demonstrate that Slug and Snail expression induced by TGFß is mediated by TGFß/ALK5 pathway, and EGF induced expression of Slug and Snail is MEK1/2 dependent
Aomatsu et al., Invest Ophthalmol Vis Sci 2011 : These data indicate that TGF-ß, but not EGF , induces sustained upregulation of SNAI1 and SNAI2 in HCECs
Cheng et al., PloS one 2012 (Cystadenocarcinoma, Serous...) : The MEK1 inhibitor PD98059 diminished the EGF induced cadherin switch and the up-regulation of Snail, Slug and ZEB1 and the EGF mediated increase in SBOT cell migration and invasion
Cheng et al., Oncogene 2013 (Ovarian Neoplasms) : Interestingly, siRNA depletion of Egr-1 attenuated the EGF induced expression of Slug , but not that of Snail
Cheng et al., J Clin Endocrinol Metab 2012 : Interestingly, our results show that EGF induced Slug but not Snail expression ... Moreover, the inhibition of EGF induced ERK1/2, p38, and Akt activation by pharmacological inhibitors attenuated EGF induced Slug expression and the down-regulation of E-cadherin, as well as subsequent cell invasion ... EGF induces human oviductal epithelial cell invasion through the activation of ERK1/2, p38, and Akt, the up-regulation of Slug , and the down-regulation of E-cadherin
Cheng et al., Cancer Lett 2013 (Ovarian Neoplasms) : This study demonstrates an important role for HIF-1a in mediating the effects of EGF on Snail, Slug and E-cadherin expression as well as invasiveness in human ovarian cancer cells
Cheng et al., Biochem Biophys Res Commun 2013 (Neoplasm Invasiveness...) : This study demonstrates an important role for HER2 in mediating the effects of EGF on Snail, Slug and E-cadherin expression as well as invasiveness in human ovarian cancer cells