◀ Back to PLD2
PLD2 — RAF1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
PLD2
→
RAF1
(increases, RAF1 Activity, PLD2 Activity)
Evidence: A role for PLD in cell proliferation is indicated from reports showing that PLD activity is elevated in response to platelet-derived growth factor (PDGF; 6), fibroblast growth factor (7, 8), epidermal growth factor (EGF; 9), insulin (10), insulin-like growth factor 1 (11), growth hormone (12), and sphingosine 1-phosphate (13). PLD activity is also elevated in cells transformed by a variety of transforming oncogenes including v-Src (14), v-Ras (15, 16), v-Fps (17), and v-Raf (18).
Text-mined interactions from Literome
Daniel et al., Biochim Biophys Acta 1999
:
The
role of
phospholipase D in stimulation of
Raf-1 and prostaglandin H synthase type-2 is emphasized
Lucas et al., Int J Oncol 2002
(Cell Transformation, Neoplastic) :
Modulation of
phospholipase D by Ras proteins
mediated by its effectors Ral-GDS, PI3K and
Raf-1