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ABL1 — RIN1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: RIN1 — ABL1 (experimental interaction detection) Hu et al., Curr Biol 2005*
• IRef Bind_translation Interaction: RIN1 — ABL1 (coimmunoprecipitation) Hu et al., Curr Biol 2005*
• IRef Hprd Interaction: RIN1 — ABL1 (in vitro) Hu et al., Curr Biol 2005*, Han et al., Proc Natl Acad Sci U S A 1997*
• IRef Intact Interaction: RIN1 — ABL1 (physical association, anti bait coimmunoprecipitation) Hu et al., Curr Biol 2005*
• IRef Intact Interaction: RIN1 — ABL1 (phosphorylation reaction, protein kinase assay) Han et al., Proc Natl Acad Sci U S A 1997*
• IRef Ophid Interaction: RIN1 — ABL1 (aggregation, confirmational text mining) Han et al., Proc Natl Acad Sci U S A 1997*
• IRef Ophid Interaction: RIN1 — ABL1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Hu et al., Curr Biol 2005 : RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration ... RIN1 is a directly binding ABL tyrosine kinase activator in cells as well as in a defined-component assay
Cao et al., J Biol Chem 2008 : RIN1 , a downstream effector of RAS, binds to the ABL SH3 and SH2 domains and stimulates ABL tyrosine kinase activity ... Importantly RIN1 mediated stimulation of ABL kinase activity was independent of activation by SRC mediated phosphorylation ... RIN1 increased the kinase activity of both ABL1 and ABL2, and this occurred in the presence or absence of ABL regulatory domains outside the SH3-SH2-tyrosine kinase domain core
Thai et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : We resolve this paradox, demonstrating that BCR-ABL1 kinase activity is regulated by RIN1 , an ABL SH3/SH2 binding protein ... BCR-ABL1 activity was increased by RIN1 overexpression and decreased by RIN1 silencing