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MAP3K1 — POLDIP2
Text-mined interactions from Literome
Yu et al., J Biol Chem 2000
:
Here we report that chelerythrine induced time- and dose dependent
activation of JNK1 and
p38 in HeLa cells, which was mediated the upstream kinases,
MEKK1 and MKK4
Gallagher et al., Nat Immunol 2007
:
Kinase
MEKK1 is
required for CD40 dependent activation of the kinases Jnk and
p38 , germinal center formation, B cell proliferation and antibody production
Sun et al., Oncol Rep 2011
:
MEKK1/MEKK4 are
responsible for TRAIL induced
JNK/p38 phosphorylation ... We found that
MEKK1/MEKK4 as opposed to ASK1, are
responsible for TRAIL induced c-Jun NH2-terminal kinase (JNK) or
p38 activation, and that their catalytic activity is repressed by the caspase-8 inhibitor, suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation