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IL10 — STAT5A

Text-mined interactions from Literome

Hashimoto et al., J Immunol 2001 : IL-10 did not change the expression of mRNA of both GM-CSFR alpha-chain and beta-chain, but inhibited tyrosine phosphorylation of STAT5 and extracellular signal regulated kinases 1 and 2 in the monocytes
Anderson et al., J Immunol 2005 : Stimulation of PI-T ( Reg ) cells in vitro with IL-10 induced Jak1 and STAT3 activation, but not STAT5 , suggesting that IL-10 is important, but not the only cytokine involved in the development of T cell tolerance
Tsuji-Takayama et al., Exp Hematol 2008 : IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells, HOZOT
Lai et al., J Biol Chem 1996 (Carcinoma, Hepatocellular...) : Unlike many hematopoietin receptors, the IL-10R did not detectably activate STAT5
Hoefsloot et al., Blood 1997 (Myelodysplastic Syndromes) : In contrast, interleukin-3 induced a normal STAT5 response in MDS cells
Yamaoka et al., J Immunol 1998 : Expression of COX-2 protein was partially reduced by treatment of anti-human GM-CSF Ab. Activation of STAT5 was inhibited by either IL-10 or dexamethasone ( Dex ), but not by aspirin ... IL-10 blocked activation of STAT5 indirectly by suppressing GM-CSF production, while Dex inhibited this activation both directly and indirectly ... Taken together, these results suggest that in addition to other transcription factors, STAT5 plays an important role in activation of monocytes by LPS, and that STAT5 is another target for IL-10 and Dex to inhibit COX-2 expression in activated monocytes
Ozaki et al., Blood 1998 : Furthermore, interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and erythropoietin also induce Crkl-STAT5 complex formation in responding cells in a stimulation dependent manner