Gene interactions and pathways from curated databases and text-mining

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EP300 — PCNA

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Cazzalini et al., Nucleic Acids Res 2008 : In vitro experiments show that inhibition of p300 HAT activity induced by PCNA is relieved by p21, which disrupts the association between recombinant p300 and PCNA ... These results indicate that p21 is required during DNA repair to regulate p300 HAT activity by disrupting its interaction with PCNA
Sang et al., J Cell Physiol 1997 : By interacting with key regulatory proteins such as the pRb family, cyclins, cyclin dependent kinases and p300/CBP of host cells, adenoviral E1A interferes with various cellular processes to provide a suitable environment for the replication of viruses