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EPHB2 — RASA1
Pathways - manually collected, often from reviews:
-
KEGG Axon guidance:
EPHB1/EPHB2/EPHB3/EPHB4/EPHB6
→
RASA1
(protein-protein, activation)
-
NCI Pathway Database EPHB forward signaling:
RasGAP (RASA1)
→
Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2)
(modification, collaborate)
Elowe et al., Mol Cell Biol 2001, Holland et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHB forward signaling:
RasGAP (RASA1)
→
Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1)
(modification, collaborate)
Elowe et al., Mol Cell Biol 2001, Holland et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHB forward signaling:
Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2)
→
Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1)
(modification, collaborate)
Elowe et al., Mol Cell Biol 2001, Holland et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database EPHB forward signaling:
Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1)
→
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Elowe et al., Mol Cell Biol 2001
Evidence: genetic interaction
-
NCI Pathway Database EPHB forward signaling:
Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1)
→
None
(modification, activates)
Elowe et al., Mol Cell Biol 2001
Evidence: genetic interaction
-
NCI Pathway Database EPHB forward signaling:
Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Elowe et al., Mol Cell Biol 2001
Evidence: genetic interaction
-
NCI Pathway Database EPHB forward signaling:
Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1)
→
None
(modification, activates)
Elowe et al., Mol Cell Biol 2001
Evidence: genetic interaction
-
Reactome Reaction:
RASA1
→
EPHB2
(reaction)
Zhang et al., Nature 1990, Yao et al., Oncogene 1995
-
Reactome Reaction:
RASA1
→
EPHB2
(indirect_complex)
Zhang et al., Nature 1990, Yao et al., Oncogene 1995
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
EPHB2
—
RASA1
(direct interaction, pull down)
Zisch et al., Oncogene 2000
-
IRef Biogrid Interaction:
EPHB2
—
RASA1
(direct interaction, pull down)
Holland et al., EMBO J 1997
-
IRef Biogrid Interaction:
EPHB2
—
RASA1
(physical association, affinity chromatography technology)
Holland et al., EMBO J 1997
-
IRef Hprd Interaction:
RASA1
—
EPHB2
(in vitro)
Zisch et al., Oncogene 2000, Holland et al., EMBO J 1997
-
IRef Ophid Interaction:
RASA1
—
EPHB2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Ye et al., Eur J Biochem 2000
(Choriocarcinoma...) :
Taken together, it is concluded that okadaic acid induces the expression of p100
RasGAP protein in JEG-3 cells
preceded by activation of
ERK and AP-1 cascade, and that this okadaic acid induced p100 RasGAP expression is independent of protein kinase C-mediated pathway but requires c-Jun/AP-1 function
Elowe et al., Mol Cell Biol 2001
(MAP Kinase Signaling System) :
Inactivation of Ras, induced by ephrin B1 stimulation of NG108 neuronal cells, requires
EphB2 tyrosine kinase activity and is
blocked by a truncated form of p120-Ras
GTPase activating protein ( p120-RasGAP ), suggesting that EphB2 signals through the SH2 domain protein p120-RasGAP to inhibit the Ras-MAPK pathway
Lin et al., Cell Microbiol 2003
(MAP Kinase Signaling System) :
Both tyrosine phosphatase activity and
GAP activity were
responsible for SptP inhibition of Raf ( Y340D ) -induced
ERK activation, but only GAP activity was responsible for inhibition of the membrane localized forms of Raf-1
Zhang et al., Am J Pathol 2006
(Carcinoma, Squamous Cell...) :
The results demonstrate that expression of
rap1GAP in oropharyngeal SCC
down-regulated active rap1,
ERK activation, and proliferation
Leander et al., PLoS Comput Biol 2012
(Tularemia) :
The model confirms that phagocytosis associated changes in the composition of the cell membrane can inhibit ERK activity and predicts that Akt and
Ras-GAP synergize to
inhibit ERK