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LEP — MSH3
Text-mined interactions from Literome
Forbes et al., Proc Natl Acad Sci U S A 2001
(Weight Gain...) :
Here we show that
leptin administered to leptin-deficient ( ob/ob ) mice
results in a large increase in peripheral
MSH levels ; further, peripheral administration of an MSH analogue results in a reversal of their abnormally low metabolic rate, in an acceleration of weight loss during a fast, in partial restoration of thermoregulation in a cold challenge, and in inducing serum free fatty acid levels
Watanobe et al., J Neurosci 2002
:
Leptin stimulated the release of
alpha-MSH in the fasted but not fed rats
Hoggard et al., J Mol Endocrinol 2004
(Obesity) :
Leptin administered to ob/ob mice in turn
increases the release of
alpha-MSH into the circulation, suggesting a possible feedback loop between the site of alpha-MSH release and the release of leptin from the adipose tissue
Breen et al., Brain Res 2005
:
Here we have examined the
effects of fasting,
leptin , and insulin on the release of AGRP and the POMC derived peptide gamma ( 3 )
-MSH from the perifused rat hypothalamus in vitro
Mastronardi et al., Neuroimmunomodulation 2005
(Bacterial Infections...) :
Our results suggest that
alpha-MSH increased
leptin release without altering its synthesis, but when LPS increased release and synthesis of leptin, alpha-MSH, although further increasing release, blocked the enhanced synthesis of leptin elicited by LPS
Lectez et al., Endocrinology 2009
:
Finally, 26RFa antagonized the
effects of
leptin on NPY expression and release, POMC expression and
alpha-MSH release, and food intake