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GDNF — SHC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → IRS1 (IRS1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → IRS1 (IRS1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SOS1 (SOS1) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SOS1 (SOS1) → RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: IRS2 (IRS2) → RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, activates)
  Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → IRS2 (IRS2) (modification, activates) Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → GRB2 (GRB2) (modification, collaborate) Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → SOS1 (SOS1) (modification, collaborate) Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SOS1 (SOS1) → RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → Gab1 (GAB1) (modification, collaborate) Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → GRB2 (GRB2) (modification, collaborate) Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Gab1 (GAB1) → RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Gab1 (GAB1) → RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Gab1 (GAB1) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction

Text-mined interactions from Literome

McAlhany et al., Alcohol Clin Exp Res 1999 : Ethanol decreases Glial Derived Neurotrophic Factor (GDNF) protein release but not mRNA expression and increases GDNF stimulated Shc phosphorylation in the developing cerebellum ... However, in the presence of the highest dose of ethanol ( 137 mM ) GDNF did stimulate Shc phosphorylation
Hayashi et al., Oncogene 2000 : In response to GDNF stimulation, SHC bound to GAB1 and GRB2 adaptor proteins as well as RET, and SHC and GAB1 were highly phosphorylated on tyrosine
He et al., Stem Cells 2008 : All 3 isoforms of Shc were phosphorylated upon GDNF stimulation, and GDNF induced the binding of the phosphorylated Ret to Shc and Grb2 as indicated by immunoprecipitation and Western blotting