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MAPK15 — RPS6KA1
Text-mined interactions from Literome
Butcher et al., Eur J Neurosci 2004
(MAP Kinase Signaling System) :
In vivo pharmacological inhibition of light induced
MAPK pathway activation
blocked RSK-1 phosphorylation, indicating that RSK-1 activity is regulated by the MAPK pathway
Larrea et al., Proc Natl Acad Sci U S A 2009
(MAP Kinase Signaling System) :
Because
RSK1 is also
activated by
MAPK , the increased cell motility and metastatic potential of cancer cells with PI3K and/or MAPK pathway activation may result in part from RSK1 activation, leading to accumulation of p27T198 in the cytoplasm, p27 : RhoA binding, inhibition of RhoA/Rock pathway activation, and loss of actomyosin stability