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IRF3 — TRAF6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 50 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of TRAF2-MAVS-TRAF6-IKBKB-VDAC1-IRF3-TBK1 (colocalization, cosedimentation through density gradient) Hou et al., Cell 2011
• MIPS Negatome - no physical interaction between proteins Interaction: TRAF6 — IRF3 (Absence of interaction, coimmunoprecipitation) Konno et al., PloS one 2009

Text-mined interactions from Literome

Jiang et al., Proc Natl Acad Sci U S A 2004 : ( ii ) Are TRAF6 , TAK1, and TAB2 also required for TLR3 mediated IRF3 activation ? ... In support of this finding, we showed that DN-TRAF6 and DN-TAK1 blocked poly ( I.C ) -induced NF-kappaB but not IRF3 activation
Sirois et al., PloS one 2011 : Knocking down the expression of TRAF6 in macrophages increased HIV-1 replication and augmented the expression of IRF7 but not IRF3
Volpi et al., Nature communications 2013 : Unveiling a previously undescribed role for TRIF and TRAF6 proteins in Toll-like receptor 9 (TLR9) signalling, we demonstrate that physical association of TLR9, TRIF and TRAF6 leads to activation of noncanonical NF-?B signalling and the induction of IRF3- and TGF-ß dependent immune-suppressive tryptophan catabolism