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GCG — LEP
Text-mined interactions from Literome
Ahrén et al., International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999
(Body Weight...) :
Leptin increases circulating glucose, insulin and
glucagon via sympathetic neural activation in fasted mice ... Human
leptin did not
affect circulating glucose, insulin or
glucagon in fasted mice after chemical sympathectomy with 6-hydroxydopamine ( 40 mg/kg iv 48 h prior to fasting ; n = 12 ) ...
Leptin increases circulating glucose, insulin and
glucagon in 24 h fasted mice by a mechanism requiring intact sympathetic nerves
Kauter et al., J Endocrinol 2000
:
Using this assay we investigated the short-term
effects of insulin, adrenaline and
glucagon ( all modulators of blood glucose ) on plasma
leptin levels
Marroquí et al., Diabetologia 2011
:
Interestingly, the
effect of
leptin on
glucagon mRNA levels was significantly reduced by Stat3 knockdown ... Our results demonstrate that
leptin can
regulate glucagon gene expression in alpha cells via a STAT3 pathway, and are important for understanding the role of leptin in glucose homeostasis
Chandra et al., Curr Opin Gastroenterol 2012
(MAP Kinase Signaling System) :
Leptin attenuates
glucagon secretion by downregulating glucagon gene expression, whereas ghrelin upregulates glucagon release by elevating intracellular calcium and phosphorylation of extracellular signal regulated kinase ( ERK )
Leclercq-Meyer et al., Mol Cell Endocrinol 1998
(Body Weight) :
Failure of human and mouse
leptin to
affect insulin,
glucagon and somatostatin secretion by the perfused rat pancreas at physiological glucose concentration
Mizuno et al., Endocrinology 1998
(Hypoglycemia) :
The
effects of
leptin on the secretion of insulin and
glucagon were examined ... In the case of sympathectomized rats, however, this stimulative
effect of
leptin on
glucagon secretion was not detected