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HNRNPH1 — IRF8
Text-mined interactions from Literome
Tamura et al., J Immunol 2005
:
We found that IRF-4 is required for the generation of CD4 ( + ) DCs, whereas
IRF-8 is, as reported previously,
essential for CD8alpha ( + )
DCs
Tailor et al., Blood 2008
(Leukemia) :
Together, this work indicates that
IRF8-partner interactions
play different roles in CD8alpha ( + )
DCs and pDCs, revealing a mechanistic separation that underlies development of these DC subsets
Tourkova et al., Cancer Immunol Immunother 2009
(Prostatic Neoplasms) :
Thus, the aim of this work was to analyze the
role of
interferon regulatory factor 8 (IRF-8) in APM protein expression and the antigen presenting capacity of
DCs developed in the tumor microenvironment ... Together, our data suggest that tumor induced inhibition of antigen processing and presenting function of
DCs is
mediated by
IRF-8 , a member of the interferon regulatory factor family
Becker et al., Blood 2012
:
Retroviral expression of
IRF-8 in multiple progenitors
led to reduced neutrophil production and increased numbers of
DCs , even in the granulocyte-macrophage progenitor ( GMP ), which does not normally possess conventional DC potential
Seillet et al., Blood 2013
:
We addressed the nature of the differentiation blocks observed in the absence of these factors and found that although all 4 factors are required for CD103+ DC development, only
Irf8 is
essential for CD8a+
DCs