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IL6 — PLD1
Text-mined interactions from Literome
Conquer et al., Osteoarthritis Cartilage 1994
:
Effect of
interleukin 1, lipopolysaccharide and phorbol esters on
phospholipase D activity in chondrocytes
Radeff et al., Cell Signal 2004
(Bone Resorption) :
Role of protein kinase A, phospholipase C and
phospholipase D in parathyroid hormone receptor regulation of protein kinase Calpha and
interleukin-6 in UMR-106 osteoblastic cells ... This is the first demonstration that
PLD mediated signalling
leads to both PKC-alpha translocation and
IL-6 promoter activation in osteoblastic cells
Sethu et al., J Immunol 2008
(Calcium Signaling...) :
Furthermore, use of antisense oligonucleotides to reduce expression of PLD1 or PLD2 demonstrated that
PLD1 is
required for TNF-alpha induced production of several important cytokines, such as IL-1beta, IL-5,
IL-6 , and IL-13, in human monocytes
L'Heureux et al., Blood 1995
:
Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils
: interleukin-8 , but not NAP-2 or GRO alpha,
stimulates phospholipase D activity