◀ Back to CD79A
BTK — CD79A
Pathways - manually collected, often from reviews:
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta bcr signaling pathway:
LYN
→
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
BLNK
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
BTK
(modification, collaborate)
-
BioCarta bcr signaling pathway:
B-cell antigen/BCR/CD79A/CD79B/Btk/LYN/BLNK complex (BCR-CD79A-CD79B-BTK-LYN-BLNK)
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
BioCarta bcr signaling pathway:
BTK
→
B-cell antigen/BCR complex complex (BCR-CD79A-CD79B)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72/SHP1 complex (CD72-PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
SHP1 (PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72/SHP1 complex (CD72-PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
SHP1 (PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
SAB (SH3BP5)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, inhibits)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
PLCgamma2 (PLCG2)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
Btk (BTK)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A)
→
Btk (BTK)
(modification, collaborate)
Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72 (CD72)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
CD72 (CD72)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
SHIP (INPP5D)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, inhibits)
-
NCI Pathway Database BCR signaling pathway:
None
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, activates)
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
None
(modification, activates)
-
Reactome Reaction:
BTK
→
CD79A
(indirect_complex)
Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Carter et al., Proc Natl Acad Sci U S A 1991, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998
Text-mined interactions from Literome
Buhl et al., J Immunol 1999
(Calcium Signaling...) :
Bruton's tyrosine kinase (Btk) plays a critical role in
B cell Ag receptor (BCR) signaling, as indicated by the X-linked immunodeficiency and X-linked agammaglobulinemia phenotypes of mice and men that express mutant forms of the kinase
Maeda et al., Oncogene 1999
(Calcium Signaling) :
Paired immunoglobulin-like receptor B ( PIR-B ) inhibits
BCR induced activation of Syk and
Btk by SHP-1
Baba et al., Proc Natl Acad Sci U S A 2001
:
The existence of such an activation mechanism is supported by the observation that the
BCR induced
Btk phosphorylation and activation are significantly reduced in BLNK-deficient B cells as well as in Syk-deficient B cells
Wu et al., J Immunol 2001
(Severe Combined Immunodeficiency) :
Although both CD72 and
BCR induced
Btk dependent ERK activation, CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity
Feldhahn et al., J Exp Med 2005
(Calcium Signaling...) :
Acting as a linker, truncated BTK enables
BCR-ABL1 dependent activation of full-length
BTK , which initiates downstream survival signals and mimics a constitutively active pre-B cell receptor
Khan et al., Infect Immun 2006
:
The relative role of
Btk dependent
B-cell receptor (BCR) signaling in the induction of antipolysaccharide ( anti-PS ) and antiprotein immunoglobulin ( Ig ) responses to an intact extracellular bacterium in vivo is unknown
Honigberg et al., Proc Natl Acad Sci U S A 2010
(Arthritis, Experimental...) :
The
Bruton tyrosine kinase (Btk) is specifically
required for
BCR signaling as demonstrated by human and mouse mutations that disrupt Btk function and prevent B-cell maturation at steps that require a functional BCR pathway
Hsu et al., Immunol Lett 2013
(Arthritis, Rheumatoid...) :
BTK is also an essential
effector of
B cell receptor (BCR) induced B cell signaling
Jiang et al., J Exp Med 1998
:
BCR mediated activation of ERK2, although maintained in Lyn-deficient cells, was abolished in Syk-deficient cells and partially inhibited in Btk-deficient cells, indicating that
BCR mediated ERK2 activation requires Syk and that sustained ERK2 activation
requires Btk