Gene interactions and pathways from curated databases and text-mining

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BTK — CD79A

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Buhl et al., J Immunol 1999 (Calcium Signaling...) : Bruton's tyrosine kinase (Btk) plays a critical role in B cell Ag receptor (BCR) signaling, as indicated by the X-linked immunodeficiency and X-linked agammaglobulinemia phenotypes of mice and men that express mutant forms of the kinase
Maeda et al., Oncogene 1999 (Calcium Signaling) : Paired immunoglobulin-like receptor B ( PIR-B ) inhibits BCR induced activation of Syk and Btk by SHP-1
Baba et al., Proc Natl Acad Sci U S A 2001 : The existence of such an activation mechanism is supported by the observation that the BCR induced Btk phosphorylation and activation are significantly reduced in BLNK-deficient B cells as well as in Syk-deficient B cells
Wu et al., J Immunol 2001 (Severe Combined Immunodeficiency) : Although both CD72 and BCR induced Btk dependent ERK activation, CD72 mediated proliferation is more resistant to blocking of ERK activity than that of BCR, as shown by the proliferation response of B cells treated with PD98059 and dibutyryl cAMP, agents that inhibit ERK activity
Feldhahn et al., J Exp Med 2005 (Calcium Signaling...) : Acting as a linker, truncated BTK enables BCR-ABL1 dependent activation of full-length BTK , which initiates downstream survival signals and mimics a constitutively active pre-B cell receptor
Khan et al., Infect Immun 2006 : The relative role of Btk dependent B-cell receptor (BCR) signaling in the induction of antipolysaccharide ( anti-PS ) and antiprotein immunoglobulin ( Ig ) responses to an intact extracellular bacterium in vivo is unknown
Honigberg et al., Proc Natl Acad Sci U S A 2010 (Arthritis, Experimental...) : The Bruton tyrosine kinase (Btk) is specifically required for BCR signaling as demonstrated by human and mouse mutations that disrupt Btk function and prevent B-cell maturation at steps that require a functional BCR pathway
Hsu et al., Immunol Lett 2013 (Arthritis, Rheumatoid...) : BTK is also an essential effector of B cell receptor (BCR) induced B cell signaling
Jiang et al., J Exp Med 1998 : BCR mediated activation of ERK2, although maintained in Lyn-deficient cells, was abolished in Syk-deficient cells and partially inhibited in Btk-deficient cells, indicating that BCR mediated ERK2 activation requires Syk and that sustained ERK2 activation requires Btk