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CCND1 — CIB1

Text-mined interactions from Literome

Zi et al., Proc Natl Acad Sci U S A 1999 (Carcinoma...) : Silibinin induced G1 arrest was associated with a marked decrease in the kinase activity of cyclin dependent kinases (CDKs) and associated cyclins because of a highly significant decrease in cyclin D1 , CDK4, and CDK6 levels and an induction of Cip1/p21 and Kip1/p27 followed by their increased binding with CDK2
Chou et al., Breast Cancer Res Treat 1999 : In the great majority of MCF10AD1 clones, accumulation in G1 phase was accompanied by reduced cyclin D1 and increased p27KIP1 protein levels
Favot et al., Thromb Haemost 2004 : The role of PDE2 and PDE4 in VEGF induced proliferation in HUVEC was investigated : 1 ) VEGF increased cAMP-hydrolytic activity by up-regulating the expression of PDE2 and PDE4 isozymes ; 2 ) VEGF increased progression in cell cycle with an increase in p42/p44 MAP kinase, cyclin A and cyclin D1 expressions and with a decrease in p21 waf1/cip1 and p27 kip1 expressions ; 3 ) EHNA ( 20 micro M ), a selective PDE2 inhibitor, RP73401 ( 10 micro M ), a selective PDE4 inhibitor blocked the VEGF induced increase in p42/p44 MAP kinase expression ; 4 ) RP73401, but not EHNA, blocked the VEGF induced increase in cyclin A and decrease in p27 kip1 expressions ; 5 ) EHNA, contrary to RP73401, enhanced the VEGF induced increase of cyclin A and decrease of p27 kip1
Festuccia et al., Endocr Relat Cancer 2009 (Disease Models, Animal...) : In vivo, azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA, Bax, Bak, p21/WAF1, and p27/KIP1 , and inhibiting the activation of Akt activity and the expression of cyclin D1 , Bcl-2, and Bcl-XL
Roy et al., Journal of molecular signaling 2010 : SFN induced the expression of p21/CIP1 and p27/KIP1 , and inhibited the expression of cyclin D1
Han et al., Cell Growth Differ 1996 : Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1 , inhibits growth, and enhances apoptosis