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CDK4 — EGF

Text-mined interactions from Literome

Terada et al., Kidney Int 1999 (Hypertrophy...) : AxCAp27, AxCAp21, and AxCAp16 all inhibited EGF stimulated CDK4 kinase activity ( to 15.6, 14.1, and 21.9 % of control, respectively )
Heo et al., Am J Physiol Cell Physiol 2006 (MAP Kinase Signaling System) : Finally, inhibition of EGFR tyrosine kinase, PKC, Ca2+ channels, or p44/42 MAPKs attenuated EGF stimulated cyclin D1, cyclin E, cyclin dependent kinase (CDK)2, and CDK4 , respectively
Yang et al., Biol Reprod 2006 : EGF and TGFB1 together inhibited CDK4 activation and DNA synthesis
Lee et al., J Cell Biochem 2006 : In addition, PD 98059 ( a MEK inhibitor ), SB 203580 ( a p38 MAPK inhibitor ), and SP 600125 ( a JNK inhibitor ) blocked the EGF induced stimulation of [ 3H ] -thymidine incorporation and CDK-2/4 expression ... Moreover, EGF increased the CDK-2, CDK-4 , cyclin D1, and cyclin E expression levels but decreased the p21 and p27 expression levels
Wierød et al., Cell Prolif 2007 : Thus, epidermal growth factor induced CDK4 activity was necessary for CDK2 activation and for hepatocyte proliferation