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EGFR — PAK1

Pathways - manually collected, often from reviews:

• WikiPathways Rac1/Pak1/p38/MMP-2 pathway: PAK1 → EGFR (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: PAK1 — EGFR Puto et al., J Biol Chem 2003*
• IRef Bind_translation Interaction: PAK1 — EGFR (coimmunoprecipitation) Puto et al., J Biol Chem 2003*
• IRef Bind_translation Interaction: PAK1 — EGFR (competition binding) Puto et al., J Biol Chem 2003*
• IRef Hprd Interaction: PAK1 — EGFR (in vivo) Puto et al., J Biol Chem 2003*
• IRef Hprd Interaction: PAK1 — EGFR (in vitro) Puto et al., J Biol Chem 2003*
• IRef Ophid Interaction: PAK1 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Sells et al., J Cell Biol 2000 : The activation of Pak1 by wounding is blocked by inhibitors of phosphatidylinositol 3-kinase, and Src family kinases, but not by an inhibitor of the epidermal growth factor receptor
He et al., Cancer J 2001 (Sarcoma, Experimental) : Using four distinct, cell-permeable, and highly specific inhibitors, namely WR-PAK18, which blocks the PAK-PIX interaction ; AG 1478, which inhibits ErbB1 kinase activity ; and AG 825 or AG 879, which inhibits ErbB2 kinase activity, we demonstrate that ( 1 ) the PAK-PIX interaction is essential for v-Ha-RAS induced malignant transformation ; ( 2 ) v-Ha-RAS requires not only ErbB1 but also ErbB2, which are activated through two independent autocrine pathways to induce both the PIX/Rac/CDC42 dependent PAK activation and malignant transformation in vitro ; and ( 3 ) a combination of AG 879 and the Src family kinase-specific inhibitor PP1 suppresses almost completely the growth of RAS induced sarcomas in nude mice
Wang et al., Circ Res 2009 (Carotid Artery Diseases...) : Thrombin also induced PAK1 activation in a time- and EGFR-Gab1-SHP2-Rac1/Cdc42 dependent manner